Background Recent studies demonstrated that Rb PET-derived myocardial perfusion reserve has a significant prognostic impact on the prediction of cardiac events in patients assessed for myocardial ischemia. Regional myocardial ischemia and late gadolinium enhancement (LGE) defined by cardiac MR imaging are also reported as significant prognosticators for future cardiac events. However, the progn...

Background In patients with PAD, ankle-brachial index (ABI) does not correlate well with time to claudication and lacks the ability to quantify tissue perfusion, therefore limiting the development of new therapies. Arterial spin labeling (ASL) MRI is a novel non-contrast technique that measures peak calf muscle perfusion noninvasively at a microvascular level. We sought to analyze the relations...

Superficial circumflex iliac artery perforator flap (SCIP) is one of the most convenient flaps to cover distal extremity defects because it conceals scar donor area well and can be raised as a thin or super-thin flap. In recent years, various chimeric SCIP were reported, including sartorius muscle, lateral femoral cutaneous nerve, bone. However, sometimes difficult on pedicle, absence communica...

OBJECTIVE Gait speed is an important predictor of health that is negatively affected by aging and type 2 diabetes. Diabetes has been linked to reduced vasoreactivity, i.e., the capacity to regulate cerebral blood flow in response to CO2 challenges. This study aimed to determine the relationship between cerebral vasoreactivity and gait speed in older adults with and without diabetes. RESEARCH ...

Vascular perfusion characteristics have been studied in dimethylbenz(a)anthracene-induced rat mammary neoplasia and compared with those of skin, skeletal muscle, salivary gland, kidney, spleen, uterus, and brain by means of an artificial perfusion technique. Perfusion of tissues and organs was measured by the microsphere tracer technique. This procedure makes possible a detailed hemodynamic ana...

The purpose of this study was to examine hemodynamic responses to graded muscle reflex engagement in human subjects. We studied seven healthy human volunteers [24 +/- 2 (SE) yr old; 4 men, 3 women] performing rhythmic handgrip exercise [40% maximal voluntary contraction (MVC)] during ambient and positive pressure exercise (+10 to +50 mmHg in 10-mmHg increments every minute). Muscle sympathetic ...

We have previously demonstrated that Drosophila synapses possess two vesicle populations-a small active zone population replenished by "fast" recycling and a much larger reserve population replenished by a slower recycling mechanism that includes endosomal intermediates. In this paper, we demonstrate that the synapses onto the tergotrochanteral muscle (TTM) are very unusual in that they possess...

Myocardial perfusion MRI is acquired with a T1-weighted dynamic MRI sequence. Fully quantitative analysis of myocardial perfusion MRI allows the absolute quantification of myocardial blood flow (MBF) through the use of complex mathematical modeling. There are essentially two main methods for quantification of absolute MBF: the linear time-invariant model and the compartment model. Maximized con...

During ex vivo myoblast differentiation, a pool of quiescent mononucleated myoblasts, reserve cells, arise alongside myotubes. Insulin/insulin-like growth factor (IGF) and PKB/Akt-dependent phosphorylation activates skeletal muscle differentiation and hypertrophy. We have investigated the role of glycogen synthase kinase 3 (GSK-3) inhibition by protein kinase B (PKB)/Akt and Wnt/beta-catenin pa...

The goals of this study were to test the following hypotheses: 1) Coronary autoregulatory adjustments to decreases in perfusion pressure occur primarily in coronary arterioles (<150 ,um in diameter). 2) Small coronary arteries (>150 ,um in diameter) can be recruited to participate in the autoregulatory adjustments as perfusion pressure is progressively lowered. 3) Small arterioles are the locat...