نتایج جستجو برای: muscle skeletal energy cost

تعداد نتایج: 1367759  

2011
Davide Basco Grazia Paola Nicchia Angelo D'Alessandro Lello Zolla Maria Svelto Antonio Frigeri

Aquaporin-4 (AQP4) is a water channel expressed at the sarcolemma of fast-twitch skeletal muscle fibers, whose expression is altered in several forms of muscular dystrophies. However, little is known concerning the physiological role of AQP4 in skeletal muscle and its functional and structural interaction with skeletal muscle proteome. Using AQP4-null mice, we analyzed the effect of the absence...

2017
Ben Stocks Jessica R. Dent Sophie Joanisse Carrie E. McCurdy Andrew Philp

Tumour protein 53 (p53) has been implicated in the regulation of mitochondrial biogenesis in skeletal muscle, with whole-body p53 knockout mice displaying impairments in basal mitochondrial content, respiratory capacity, and enzyme activity. This study aimed to determine the effect of skeletal muscle-specific loss of p53 on mitochondrial content and enzyme activity. Mitochondrial protein conten...

2015
Sabzali Javadov Sehwan Jang Natividad Rodriguez-Reyes Ana E. Rodriguez-Zayas Jessica Soto Hernandez Tanja Krainz Peter Wipf Walter Frontera

Mitochondrial dysfunction plays a central role in the pathogenesis of sarcopenia associated with a loss of mass and activity of skeletal muscle. In addition to energy deprivation, increased mitochondrial ROS damage proteins and lipids in aged skeletal muscle. Therefore, prevention of mitochondrial ROS is important for potential therapeutic strategies to delay sarcopenia. This study elucidates t...

Journal: :Journal of molecular endocrinology 2013
Weiwei Fan Annette R Atkins Ruth T Yu Michael Downes Ronald M Evans

Skeletal muscle is the largest organ in the human body and is the major site for energy expenditure. It exhibits remarkable plasticity in response to physiological stimuli such as exercise. Physical exercise remodels skeletal muscle and enhances its capability to burn calories, which has been shown to be beneficial for many clinical conditions including the metabolic syndrome and cancer. Nuclea...

Journal: :Obesity reviews : an official journal of the International Association for the Study of Obesity 2017
Carlos K Katashima Vagner R Silva Tatyanne L Gomes Claude Pichard Gustavo D Pimentel

This systematic review aimed at addressing the ursolic acid actions as an adjunctive treatment of the obesity-mediated metabolic abnormalities. To explore our aims, we used the literature search including clinical and animal studies using the Medline and Google Scholar (up to December 2015). Out of 63 screened studies, 17 presented eligibility criteria, such as the use of ursolic acid on adipos...

Journal: :EBioMedicine 2016
Yong Zhang Changyin Li Hu Li Yipeng Song Yixia Zhao Lili Zhai Haixia Wang Ran Zhong Huiru Tang Dahai Zhu

Obesity has been linked to many health problems, such as diabetes. However, there is no drug that effectively treats obesity. Here, we reveal that miR-378 transgenic mice display reduced fat mass, enhanced lipolysis, and increased energy expenditure. Notably, administering AgomiR-378 prevents and ameliorates obesity in mice. We also found that the energy deficiency seen in miR-378 transgenic mi...

2015
Rexford S. Ahima Hyeong-Kyu Park

Skeletal muscle is the largest organ of the body in non-obese individuals and is now considered to be an endocrine organ. Hormones (myokines) secreted by skeletal muscle mediate communications between muscle and liver, adipose tissue, brain, and other organs. Myokines affect muscle mass and myofiber switching, and have profound effects on glucose and lipid metabolism and inflammation, thus cont...

2013
A. Aria Tzika Caterina Constantinou Arunava Bandyopadhaya Nikolaos Psychogios Sangseok Lee Michael Mindrinos J. A. Jeevendra Martyn Ronald G. Tompkins Laurence G. Rahme

Mitochondria integrate distinct signals that reflect specific threats to the host, including infection, tissue damage, and metabolic dysfunction; and play a key role in insulin resistance. We have found that the Pseudomonas aeruginosa quorum sensing infochemical, 2-amino acetophenone (2-AA), produced during acute and chronic infection in human tissues, including in the lungs of cystic fibrosis ...

2009
John R. Ussher Jagdip S. Jaswal Cory S. Wagg Heather E. Armstrong David G. Lopaschuk Wendy Keung Gary D. Lopaschuk

Ussher JR, Jaswal JS, Wagg CS, Armstrong HE, Lopaschuk DG, Keung W, Lopaschuk GD. Role of the atypical protein kinase C in regulation of 5 -AMP-activated protein kinase in cardiac and skeletal muscle. Am J Physiol Endocrinol Metab 297: E349–E357, 2009; doi:10.1152/ajpendo.00009.2009.—During metabolic stress, phosphorylation and activation of 5 -AMP-activated protein kinase (AMPK) becomes a majo...

2009
Meghan Kelly Marie-Soleil Gauthier Asish K. Saha Neil B. Ruderman

OBJECTIVE Interleukin-6 (IL-6) directly activates AMP-activated protein kinase (AMPK) in vivo and in vitro; however, the mechanism by which it does so is unknown. RESEARCH DESIGN AND METHODS We examined this question in skeletal muscle using an incubated rat extensor digitorum longus (EDL) muscle preparation as a tool. RESULTS AMPK activation by IL-6 coincided temporally with a nearly three...

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