Gloriosa superba (Kembang Sungsang, local name) belongs to the monocotyledoneae class and Liliaceae family. This plant is known as a medicinal its pharmacological effects have been developed both traditional modern. All parts of superba, especially tubers seeds, contain alkaloids namely colchicine gloriosine. The content colchicides in other plants about 0.1 - 0.9% 0.8% respectively. Colchicine...

N-methyl-N'-nitro-N-nitrosoguanidine (NTG) in high concentrations inactivates extracellular simian virus 40. No mutants were found in stocks of virions partially inactivated by NTG under the experimental conditions employed. In contrast, NTG in low concentrations inhibits the intracellular replication of simian virus 40 and is an effective mutagen of the intracellular virus. Six temperature-sen...

Ethylene oxide is a highly reactive epoxide gas and a direct alkylating agent with chemical properties that make it a potent mutagen and a potential human carcinogen.4 It has been used commercially in the United States since the 1950s for sterilization of medical supplies, pharmaceutical products, and spices. NIOSH estimates that 270,000 workers may be exposed annually, with high levels of expo...

Directly active mutagens are formed on exposure of the promutagen benzo[a]pyrene to gaseous pollutants in smog. In simulated atmospheres containing 1 part per million nitrogen dioxide and traces of nitric acid, directly mutagenic nitro derivatives are readily formed from both benzo[a]pyrene and perylene, a non-mutagen in the Ames reversion assay. Possible formation of direct mutagens by such re...

The work considers and distinguishes the psychopathological symptom complexes of depression in adolescents that are resistant to therapy: anxious, obsessive, behavioral. level spontaneous induced mutagenesis blood lymphocytes with was determined vitro, which twice chromosomal aberrations after introducing a mutagen into culture mixture, indicates pronounced individual group hidden instability p...