abstract background and objective: a high level of homogeneity observed within all bacteria in the mycobacterium tuberculosis complex makes a property that seriously challenges traditional biochemical-based identification methods of these pathogens in the laboratory. the work presented here was conducted to characterize mycobacterium tuberculosis complex isolates in golestan, northern iran. mat...

In summary, in order to control tuberculosis, we require a rapid diagnosis of TB patients, who act as the source of disease; and if remain untreated, these patients can spread the disease throughout the population. Therefore, we need to introduce the new approach for quick and accurate identification of Mycobacterium tuberculosis, and CYP141 gene is a new approach for rapid and accura...

The immunogenicity of the candidate tuberculosis (TB) vaccine MVA85A may be enhanced by aerosol delivery. Intradermal administration was shown to safe in adults with latent TB infection (LTBI), but data are lacking for aerosol-delivered vaccines this population. We carried out a Phase I trial evaluate safety and delivered UK LTBI (NCT02532036). Two volunteers were recruited, well-tolerated no c...

introduction: mycobacterium marinum infection is the most common nontuberculous mycobacterial skin lesions. it results from skin injury and contact with contaminated water, fish, or shellfish; its infections have low frequency, nonspecific symptoms and lack of specific identification methods that can alter correct diagnosis.this study designed about cases that reported from iran and comparing t...

background and objectives: the increase of infections caused by nontuberculous mycobacteria (ntm) is receiving increasing attention worldwide. mycobacterium fortuitum is encountered with increasing frequency in clinical laboratories of iran. materials and methods: sequence variation of 48 m. fortuitum clinical isolates, were investigated by sequence analysis of the 16s-23s internal transcribed ...

abstractmammary tissue, skeletal muscle, and spleen are less frequently affected by mycobacterium tuberculosis (tb).the most common age for breast tb is between 50 and 70. on this article, we are reporting a 72-year-old womanwho presented with chronic cough, lobar consolidation in right middle lobe (rml) on the cxr, and a massin her right breast revealed on the physical examination. biopsy from...

the biodegradation of secondary amines is particularly important due to their propensity for conversion either chemically or microbiologically to n-nitrosamines which are potent carcinogens. in this research, a weak gram-positive organism was isolated from river and identified as mycobacterium. this mycobacterium grows slowly and effectively utilizes piperazine as the sole source of organic, ca...

tuberculosis (tb) is an important health problem in developing countries, with varying clinical presentations depending on the organs/systems involved. to study the spectrum of clinical and paraclinical aspects of extra pulmonary tb in children suffering from pulmonary tb. this study has been carried out on 65 children with tuberculosis, admitted in tb wards of national research institute of tu...

background bcg (bacille calmette-guerin) vaccine is an attenuated live vaccine administered to prevent tuberculosis. disseminated infection due to bcg is a rare life threatening complication of this vaccine, especially in immunocompromised patients. objectives the current study evaluated the sensitivity pattern of the bcg strain supplied by the institute de pasteur, iran against anti-mycobacter...

Pseudomonas aeruginosa ExoU, a type III secretory toxin and major virulence factor with patatin-like phospholipase activity, is responsible for acute lung injury and sepsis in immunocompromised patients. Through use of a recently updated bacterial genome database, protein sequences predicted to be homologous to Ps. aeruginosa ExoU were identified in 17 other Pseudomonas species (Ps. fluorescens...