Methods We analyzed medical records of 78 children, admitted to Chungnam National University Hospital and diagnosed with lobar pneumonia by chest X-rays between March 2010 and December 2011. White blood cells, C-reactive protein (CRP), procalcitonin (PCT), specific antibodies to M. pneumoniae, and cold agglutinin (CA) were measured at admission. Children were divided into 2 groups: those with M...

Background The concept of using antibiotics to treat Scleroderma stems from research done initially by Thomas M Brown, MD at the National Institutes of Health, Johns Hopkins and the Rockefeller Institute. Brown used antibiotic therapy to treat a variety of autoimmune diseases based on the theory that arthritic diseases, including Scleroderma, are caused by mycoplasma or bacterial infections. My...

Adhesins and adhesin-related accessory proteins of pathogenic mycoplasmas are required for cytadherence and the subsequent development of disease pathology. The classic example has been Mycoplasma pneumoniae, which causes primary atypical pneumonia in humans. Mutants of M. pneumoniae defective in adhesins (P1 and P30) or in adherence-accessory proteins (HMW1 through HMW4) are unable to colonize...

We report an outbreak of severe respiratory disease associated with a novel Mycoplasma species in ferrets. During 2009-2012, a respiratory disease characterized by nonproductive coughing affected ≈8,000 ferrets, 6-8 weeks of age, which had been imported from a breeding facility in Canada. Almost 95% became ill, but almost none died. Treatments temporarily decreased all clinical signs except cou...

Mycoplasma pneumonia is a major cause of respiratory infections in school-aged children. Most M. pneumonia infections in adults involve the respiratory tract. Extrapulmonary manifestations of M. pneumonia infection may be found in the skin, cardiovascular, neurologic and hematologic systems. Concomitant liver disease is rare in adults. Here, we report an unusual case of a patient who presented ...

Infection by Mycoplasma bovis (M. bovis) can induce diseases, such as pneumonia and otitis media in young calves and mastitis and arthritis in older animals. Here, we report the finished and annotated genome sequence of M. bovis strain Hubei-1, a strain isolated in 2008 that caused calf pneumonia on a Chinese farm. The genome of M. bovis strain Hubei-1 contains a single circular chromosome of 9...

Mycoplasmas cause chronic inflammation and are implicated in asthma. Mast cells defend against mycoplasma infection and worsen allergic inflammation, which is mediated partly by histamine. To address the hypothesis that mycoplasma provokes histamine release, we exposed mice to Mycoplasma pulmonis, comparing responses in wild-type and mast cell-deficient KitW-sh/KitW-sh (W-sh) mice. Low histamin...

Polyclonal and monoclonal antibodies to Mycoplasma pneumoniae protein P1 were nonreactive with whole-cell or soluble preparations of M. genitalium and M. gallisepticum. However, radioimmunoprecipitation performed with hyperimmune rabbit sera raised against each mycoplasma species indicated antigenic cross-reactivity between M. pneumoniae and M. genitalium.

Pneumonia presenting at birth or occurring within first 48 hours of life is most commonly caused by E. coli, Streptococci, Klebsiella aerobacter or Enterococci(1). Congenital pneumonia produces intrauterine death in 16-20% of neonates(l). Early diagnosis and adequate treatment can reduce the mortality to a great extent. We report a case of congenital pneumonia caused by Klebsiella pneumoniae wi...

We report an 11-year-old girl, who suffered from Mycoplasma pneumoniae pneumonia, meningitis, and mild, bilateral, acute otitis media, with subsequent severe, mixed hearing loss. The patient presented extremely high Mycoplasma pneumoniae complement fixation and cold hemagglutinin titers, the unique chest x-rays indicating mycoplasma pneumonia, and cerebrospinal fluid suggestive of meningitis. A...