735 For the last four decades the diagnosis of MI has been based on the WHO criteria. The definition of MI required the presence of at least two of the following three factors: clinical history of ischemic chest pain; serial changes in ECG; a rise and fall in serum cardiac enzymes. These criteria have been extensively modified by the clinicians in their application: chest pain is often non-spec...

Methods CK, CK-MB, and cTn I were prospectively assessed in 100 patients who underwent elective PCI during the period between Jan 2012 and Jan 2013. Patients were subjected to history taking, routine laboratory investigations, electrocardiogram ( ECG), cardiac biomarkers assay, and Echocardiography pre and post PCI. The primary end point was death, myocardial infarction or severe, recurrent isc...

Sepsis has high incidence and mortality rates around the world. The role of cardiac depression in myocardial dysfunction during sepsis remains to be elucidated. This review attempts to summarize our understanding of the anatomical, histopathological, and pathophysiological mechanisms behind cardiac dysfunction. Biomarkers to detect cardiac depression have been used to recognize developing probl...

Apparent Diffusion coefficient (ADC), T1 and T2 quantitative indexes of the myocardium in athletes before, during and after extreme mountain ultra-marathon: correlation with myocardial damages and inflammation biomarkers Magalie Viallon, Kevin Moulin, Caroline Le Goff, Juliette Didier, Ruud B van Heeswijk, Matthias Stuber, Charles de Bourguignon, Laurent Gergelé, Grégoire P Millet, Olivier Beuf...

Introduction: Myocardial protection is one of the key points during cardiac surgery. Inadequate myocardial in cross-clamping period an issue concern Cardioplegic solutions improve tolerance ischemia and reperfusion by preserving energy reserves, preventing osmotic, electrolyte imbalances acidosis. Warm blood cardioplegia (WBC) has had a profound impact, especially coronary artery bypass surgery...

Background Both HCM and DCM exhibit variable clinical outcomes. Unfortunately, our ability to risk stratify and characterize disease mechanisms in these patients remains poor, and improved biomarkers are needed. Myocardial fibrosis, both focal and diffuse, is a feature of both HCM and DCM and focal myocardial fibrosis, as assessed by LGE, has been recently identified as a predictor of cardiac d...

The cardiac troponins are integral components of the myofibrillary apparatus and they regulate muscle contraction. The measurement of cardiac troponins has replaced other biomarkers for the specific detection of myocardial necrosis and for the diagnosis of myocardial infarction. The tissue specificity plus sensitivity of the measurement technology has meant that cardiac damage can be detected i...

Background: Myocardial infarction is the leading cause of death worldwide. Patients suffering from myocardial with a ST-elevated segment termed as STEMI experience high risk and these patients report recurrent attacks even more compared to other MI patients. Objective: The goal this study was check that either oncostatin M (OSM) can be used biomarker for evaluation Study design: This control-ex...

BACKGROUND Subclinical diabetic cardiomyopathy (DCM) is frequent in asymptomatic subjects with type 2 diabetes (T2DM). We sought the response of functional and fibrosis markers to therapy in a trial of aldosterone antagonism for treatment of DCM. METHODS Biochemical, anthropometric, and echocardiographic data were measured in 225 subjects with T2DM. Myocardial function was evaluated with stan...

Adverse left ventricular (LV) remodeling with persistent and worsening LV dysfunction after acute myocardial infarction (AMI) is strongly associated with long-term cardiovascular morbidity and mortality. Hence, identification of patients with low likelihood of LV contractile recovery despite successful reperfusion therapy represents an important issue in clinical cardiology, with significant im...