Cyclophosphamide is the most commonly used alkylating agent for anti cancer chemotherapy and immunosuppression. Halothane and sevoflurane are volatile anesthetics and halothane has been demonstrated to enhance cyclophosphamide toxicity. However, the interaction between sevoflurane and cyclophosphamide has not yet been investigated. We evaluated the effects of cyclophosphamide on myocardial depr...

AIMS To evaluate the prognostic implications of results from exercise testing, and of antianginal treatment among patients with chronic stable angina pectoris. MATERIAL AND METHODS Out of 809 patients in the Angina Prognosis Study In Stockholm (APSIS), 731 (511 men) performed evaluable exercise tests before and after 1 month on double-blind treatment with metoprolol or verapamil. During a med...

Clinical studies have demonstrated the predictive values of changes in electrocardiographic (ECG) parameters for the preexisting myocardial ischemic infarction. However, a simple and early predictor for the subsequent development of myocardial infarction during the ischemic phase is of significant value for the identification of ischemic patients at high risk. The present study was undertaken b...

Depressive disorder, as defined by standardised research criteria, is recorded in 13–19% of patients at the time of myocardial infarction (MI). 1–7 The disorder is important in MI patients because depression is associated with several adverse outcomes: increased mortality, 1 5–7 angina, 2 arrhythmias, 2 6 8 rehospitalisation, prolonged disability, and continued smoking. Increased mortality Ther...

those with ST elevation myocardial infarction, whereas ‘primary’ therapy for those with non-ST elevation acute coronary syndromes is antithrombotic therapy (aspirin, heparin or low molecular weight heparin and/or glycoprotein IIb/IIIa inhibitors). Given the importance of ST elevation in discriminating acute myocardial infarction, Menown and colleagues conducted a comprehensive study of the exac...

The presence of electrocardiographic ST depression in acute infarction remains controversial and poorly explained. A combined animal and modeling study was performed to evaluate the source of ST changes in acute infarction. In anaesthetized sheep, small infarcts showed uniform ST elevation over the infarction whereas larger infarcts showed marked ST depression over the normal myocardium in addi...

This study was undertaken to determine whether the site of ST depression on 12-lead exercise electrocardiography can identify the ischemic site assessed by myocardial Tl-201 emission computed tomography in 409 patients with transient defects. ST depression in some leads was more frequent in those with inferior or lateral ischemia than in those with anterior ischemia. In 214 patients with ST dep...

BACKGROUND Elevated scores on depression symptom questionnaires predict rehospitalization after acute myocardial infarction (AMI). Whether the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, depressive disorders predict rehospitalization after AMI is unknown. METHODS AND RESULTS Participants (n=766) in an Enhancing Recovery and Coronary Heart Disease ancillary study wer...

OBJECTIVES The purpose of this research was to explore the prospective relationship between the use of beta-blockers and depression in myocardial infarction (MI) patients. BACKGROUND Beta-blocker use has been reported to be associated with the development of depression, but the methodological quality of studies in this field is weak. METHODS In a multicenter study, MI patients (n 127 non–beta-b...

Victims of chlorine (Cl2) inhalation that die demonstrate significant cardiac pathology. However, a gap exists in the understanding of Cl2-induced cardiac dysfunction. This study was performed to characterize cardiac dysfunction occurring after Cl2 exposure in rats at concentrations mimicking accidental human exposures (in the range of 500 or 600 ppm for 30 min). Inhalation of 500 ppm Cl2 for 3...