The time of acute myocardial infarction was determined in all 1,741 patients of the ISAM (Intravenous Streptokinase in Acute Myocardial Infarction) Study, based on onset of clinical symptoms and evaluation of plasma CK-MB enzyme time-activity curves. The incidence of myocardial infarction was markedly increased between 6:00 AM and 12:00 noon compared with other times of day (p<0.001). Myocardia...

Myocardial infarction (MI) is the most prevalent disease with severe mortality, and hypoxia-induced cardiac injury cardiomyocyte apoptosis are significant harmful consequences of this disease. The cross talk between hypoxia signaling glycolysis energy flux plays a critical role in modulating MI-related heart disorder. However, underlying mechanism remains unclear. Here, we aimed to explore effe...

Myocardial bridge is a benign congenital anomaly in which a segment of major epicardial coronary arteries descends into the myocardium for a variable distance. Myocardial bridge is most often single and located in the middle part of the left anterior descending artery. The presence of more than one myocardial bridge in coronary arteries is very rare. We present a patient with more than one myoc...

Coronary heart disease (CHD) is a generic designation for group of related syndromes resulting from myocardial ischemia – an imbalance between cardiac blood supply (perfusion) and oxygen demand. Visfatin (VF) recently discovered adipokine with different functions, mainly found in visceral adipose tissue mimics insulin lowering plasma glucose levels and, emerges as player the development progres...

Summary Aortic valve stenosis (AS) is predominantly caused by degenerative calcification in patients over 70 years. It obstructs the left ventricular outflow tract. The result concentric hypertrophy (LVH) wall stress and ischemia-induced myocardial fibrosis. [1] According to European Association of Cardiothoracic Surgery, all high-grade AS are indicated for intervention [2]. One most recommenda...