Nitric oxide (NO) is involved in the control of myocardial metabolism. In normoperfused myocardium, NO synthase inhibition shifts myocardial metabolism from free fatty acid (FFA) toward carbohydrate utilization. Ischemic myocardium is characterized by a similar shift toward preferential carbohydrate utilization, although NO synthesis is increased. The importance of NO for myocardial metabolism ...

OBJECTIVES The aim of the study was to assess the prognostic value of myocardial viability and ischemia detected by dobutamine stress echocardiography (DSE) in patients with acute myocardial infarction (AMI) treated with thrombolysis. BACKGROUND DSE can detect myocardial viability and ischemia early after AMI, but the prognostic importance of viability and ischemia in these patients has yet t...

Silent myocardial ischemia is defined as objective documentation of myocardial ischemia in the absence of angina or anginal equivalents. The first description of silent ischemia date to the 1970s, but despite intensive investigation, its pathophysiology, detection, prevalence, and clinical significance are still debated. The need and the benefit of treating silent ischemia, particularly in pati...

Background. Exercise-induced abnormalities during thallium-201 scintigraphy that normalize at rest frequently occur in patients with hypertrophic cardiomyopathy. However, it is not known whether these abnormalities are indicative of myocardial ischemia. Methods and Results. Fifty patients with hypertrophic cardiomyopathy underwent exercise 20UT1 scintigraphy and, during the same week, measureme...

Growth factors and inflammatory Ras homolog gene family member A (RhoA)/coiled-coil containing protein kinase 1 (ROCK1) pathway have been shown to regulate isoproterenol (ISO)-induced myocardial ischemia. However, the association between matrine and myocardial ischemia remains to be elucidated. The objective of this study was to explore whether matrine ameliorates ISO-induced myocardial ischemi...

BACKGROUND Exercise-induced abnormalities during thallium-201 scintigraphy that normalize at rest frequently occur in patients with hypertrophic cardiomyopathy. However, it is not known whether these abnormalities are indicative of myocardial ischemia. METHODS AND RESULTS Fifty patients with hypertrophic cardiomyopathy underwent exercise 201Tl scintigraphy and, during the same week, measureme...

1. Perfusion imaging to detect myocardial ischemia Myocardial ischemia occurs when insufficient blood flow, or perfusion, to the myocardium results in inadequate delivery of oxygen as well as inadequate removal of metabolites. These conditions may occur at rest due to insufficient oxygen supply (supply ischemia) or at stress due to a failure to sufficiently accommodate increased oxygen demand (...

UNLABELLED BACKGROUND Chest pain, a key element in the investigation of coronary artery disease is often regarded as a benign prognosis when present in panic attacks. However, panic disorder has been suggested as an independent risk factor for long-term prognosis of cardiovascular diseases and a trigger of acute myocardial infarction. OBJECTIVE Faced with the extreme importance in differen...

Hydrogen sulfide (H2S) is believed to be involved in numerous physiological and pathophysiological processes, and now it is recognized as the third endogenous signaling gasotransmitter, following nitric oxide and carbon monoxide; however, the effects of H2S on inflammatory factors in acute myocardial ischemia injury in rats have not been clarified. In the present study, sodium hydrosulfide (NaH...

Myocardial ischemia-reperfusion injury is a major cause of morbidity and mortality in developed countries. To date, the only treatment of complete ischemia is to restore blood flow; thus the search for new cardioprotective approaches is absolutely necessary to reduce the mortality associated with myocardial ischemia. Ischemia has long been considered to result in necrotic tissue damage but the ...