INTRODUCTION [13N]ammonia PET allows quantification of myocardial perfusion. The similarity between peripheral flow and myocardial perfusion is unclear. We compared perfusion flow in the myocardium with the upper limb during rest and adenosine stress [13N]ammonia PET to establish whether peripheral perfusion reserve (PPR) correlates with MPR. METHODS [13N]ammonia myocardial perfusion PET-scan...

INTRODUCTION Randomized and nonrandomized clinical trials have tried to assess whether or not TMR patients experience an increase in myocardial perfusion. However there have been inconsistencies reported in the literature due to the use of different nuclear imaging modalities to test this metric. The primary purpose of this meta-analysis was to determine whether SPECT, MUGA and PET scans demons...

We used first-pass contrast-enhanced MRI to quantatively measure the myocardial Ktrans, a parameter indicating myocardial perfusion and vascular permeability, in mice with or without vasodilation. We measured a significant increase in myocardial Ktrans with vasodilation. We believe this may be the first report showing that first-pass imaging can quantify increased myocardial perfusion in mice r...

The ability of contrast echocardiography to assess regional myocardial perfusion during cardiopulmonary bypass in a dog model for coronary artery bypass surgery was evaluated. Sonicated Renograffin-76 microbubbles (meglumin diatrigoate and sodium diatrigoate) were injected into an aortic root proximal to an aortic occlusion clamp root while dogs were on cardiopulmonary bypass, with the heart ar...

Though angina suggests myocardial ischaemia, this symptom is poorly related to the extent, severity, or site of impaired myocardial perfusion. Electrocardiography during graded exercise is commonly used as a clinical tool to assess the extent and site of ischaemia but it is a poor guide. Myocardial oxygen extraction is almost maximal in the resting mammalian heart, an obligatory aerobic organ. ...

BACKGROUND A novel 3-dimensional left ventricular (LV) mapping system uses low-intensity magnetic field energy to determine the location of sensor-tipped electrode catheters within the LV. Using this system, we sought to distinguish between infarcted, ischemic, and normal myocardium by comparing LV electromechanical mapping data with myocardial perfusion imaging studies. METHODS AND RESULTS U...

Background Echo and nuclear studies have shown that coronary flow changes with the cold pressor test (CPT). CPT has been used to measure coronary flow response because it provides an endothelium-dependent coronary vasodilation that is sensitive for detecting early changes in coronary endothelial function. There was also a study showed myocardial perfusion increases during CPT with first pass pe...

Background Stress myocardial perfusion MRI allows for accurate detection of flow-limiting stenosis in the coronary artery. However, reduced diagnostic accuracy of stress myocardial perfusion MRI was reported in patients with coronary artery bypass grafts (CABG). Flow measurement in CABG is another MR approach that permits functional assessment of graft stenosis. The purpose of this study was to...

The clinical use of radioisotopes in the evaluation of patients with ischemic heart disease is largely based on noninvasive methodology suitable for visualizing myocardial perfusion. Although contrast echocardiography and magnetic resonance imaging have been proposed recently for the same purpose, at present most of the noninvasive tests for assessing myocardial perfusion reside in nuclear card...

Epicardial adipose tissue is a source of pro-inflammatory cytokines and has been linked to the development of coronary artery disease. No study has systematically assessed the relationship between local epicardial fat volume (EFV) and myocardial perfusion defects. We analyzed EFV in patients undergoing SPECT myocardial perfusion imaging combined with computed tomography (CT) for attenuation cor...