OBJECTIVES For pharmacological reasons, the effect of the combination of MTX and SSZ may be different in RA patients who are naïve to these drugs compared to patients with an insufficient response to one of them. Therefore, we compared the results of randomized controlled trials (RCTs) on the combination of MTX and SSZ in naïve patients and in patients with an insufficient response to SSZ. ME...

INTRODUCTION Emtricitabine/rilpivirine/tenofovir (EVP) is a fixed-dose combination of antiretrovirals (ARV) approved by the European Medicines Agency in November 2011 and introduced in Italy in February 2013. It is a once-a-day single tablet and is licensed in Europe for use only in ARV-naïve patients with a viral load (VL) ≤100,000 copies/mL. OBJECTIVE To identify factors that may be associa...

BACKGROUND Malignancy risk with tumour necrosis factor inhibitor (TNFi) therapy remains unclear. Our primary aim was to assess malignancy risk with TNFi therapy in a cohort of Australian patients with rheumatoid arthritis (RA). We also assessed risk in a biologic-naïve group. METHODS Demographic data of all RA patients enrolled in the Australian Rheumatology Association Database before 25 Oct...

Background: Intestinal protozoa transmitted by food are the most common opportunistic parasites among the HIV+/AIDS patients. As, there is no report about prevalence of food-borne intestinal parasites in such patients in Yazd, so this study was performed to determine the prevalence of intestinal protozoa in the HIV+/AIDS patients in comparison with HIV- individuals. Methods: A case-control stu...

Lopinavir/ritonavir (LPV/r) is the first ritonavir-boosted protease-inhibitor used in second-line anti-retroviral treatment (ART) in resource-limited regions. To evaluate the efficacy and safety outcomes of LPV/r in treatment-naïve and -experienced HIV-infected adults and pregnant women, we performed a meta-analysis of randomized controlled trials. Ten cohorts from 8 articles involving 2,584 AR...

Sjögren's syndrome (SS) is an autoimmune disease characterised by breach of self-tolerance towards nuclear antigens resulting in high affinity circulating autoantibodies. Although peripheral B cell disturbances have been described in SS, with predominance of naïve and reduction of memory B cells, the stage at which errors in B cell tolerance checkpoints accumulate in SS is unknown. Here we dete...

purpose : up to 70% of patients with acquired immunodeficiency syndrome (aids) have aids-related ocular involvements which may severely affect their quality of life caused by visual impairment. this study was designed to investigate the ocular manifestations in patients infected with human immunodeficiency virus (hiv). methods : in this case series study, 41 hiv positive patients were investiga...

Regulatory T cells (T(reg) cells) are increased in context of malignancies and their expansion can be correlated with higher disease burden and decreased survival. Initially, interleukin 2 (IL-2) has been used as T-cell growth factor in clinical vaccination trials. In murine models, however, a role of IL-2 in development, differentiation, homeostasis, and function of T(reg) cells was establishe...

Objective: Describing the tumors diagnosed in patients with HIV, hospitalized in the Department of Infectious Diseases of the CHU YO. Patients and method It was about a cross-sectional study of the prospective collection of tumors diagnosed in HIV patients hospitalized in the Department of Infectious Diseases from 1st January 2013 to 28th February 2014. All HIV-positive patients with a diagnose...

BACKGROUND Antiretrovirals (ARVs) could lead to clinically significant nephrotoxicity and as such will require dose adjustments in the presence of renal insufficiency. OBJECTIVE To explore renal function estimating equations as alternatives for glomerular filtration rate (GFR) measurement in a stable cohort of HIV-infected patients. METHOD In estimating renal insufficiency in Ghanaian HIV-i...