Hepatocyte apoptosis is a key event in nonalcoholic fatty liver disease (NAFLD), and serum apoptotic markers are emerging as surrogate markers for NAFLD. We studied the role of caspase-cleaved cytokeratin18 in the diagnosis of fibrosis in a cohort of 127 morbidly obese patients and also performed a review of the literature biomarkers of NAFLD and fibrosis. Here, we found that cleaved caspase 18...

background: polycystic ovary syndrome (pcos) is highly associated with non-alcoholic fatty liver disease (nafld). there are extensive ethnic differences in the clinical manifestations, pathological changes, and ovarian changes in women with pcos. objective: to investigate the prevalence and clinical characteristics of nafld in chinese women with pcos. materials and methods: non-pregnant women w...

OBJECTIVE To study the frequency of non-alcoholic fatty liver disease (NAFLD), its relationship to clinical and biochemical variables, and the effect 12-month's lifestyle intervention in obese children and adolescents. METHODS Thirty-six obese patients aged 7 to 18 years, 42% female and 58% male, 72.2% prepubertal and 27.8% pubertal, were selected. Anthropometric measurements and glucose, ins...

INTRODUCTION Hypoadiponectinaemia is an important risk factor for non-alcoholic fatty liver disease (NAFLD). However, little is known about its role in the Chinese population. This study sought to assess the prevalence of NAFLD and its association with hypoadiponectinaemia in middle-aged and elderly Chinese. MATERIAL AND METHODS We conducted a population-based cross-sectional study in an urba...

Liver fat, more than visceral fat is associated with type 2 diabetes (T2D). Although the relationship of nonalcoholic fatty liver disease (NAFLD) was studied in the light of the metabolic syndrome and type 2 diabetes, the relationship of NAFLD with proinsulin and adiponectin levels reflecting the β-cells dysfunction and respectively adipocytes secretion was less studied. In 112 patients (41 men...

OBJECTIVE To evaluate the associations between nonalcoholic fatty liver disease (NAFLD) and atherosclerosis. METHODS AND RESULTS A total of 8632 participants aged ≥ 40 years from Jiading district, Shanghai, were included in the present study. The presence of NAFLD was evaluated by ultrasonography. Carotid intima-media thickness (CIMT) and brachial-ankle pulse wave velocity (ba-PWV) were measu...

BACKGROUND/AIMS Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide. Along with the increase in the incidence of NAFLD and associated obesity, an increase in gallbladder disease (GD) has been noted. This has led to the identification of a new disease entity called fatty GD. There is a gap in the literature on the dynamics of gallbladder function...

BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is a continuously increasing cause of chronic liver disease and a health burden in all populations affected by the obesity and metabolic syndrome pandemic. Cirrhotic alterations or hepatocellular carcinoma developing from NAFLD may require liver transplantation (LTx). METHODS Current literature was screened for data on LTx in the setting of...

Serum liver enzyme levels are often used effectively for the evaluation of nonalcoholic fatty liver disease (NAFLD). We aimed to investigate the associations between serum liver enzyme levels and risks for NAFLD in over 8000 cases in a large-scale analysis. A cross-sectional survey with multiple stages and random samplings was performed from May 2007 to May 2009 on 8102 workers at Tongji Univer...

BACKGROUND & AIMS Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. The two linked studies presented herein aimed to identify and verify new biomarkers for NAFLD. METHODS First, 70 serum samples were analyzed using proteomics approaches to identify potential biomarkers for NAFLD. Second, a total of 6944 initial NAFLD-free subjects were follow...