We generated two hiPSC clones from a patient with sporadic late-onset Alzheimer’s disease (AD-iPSCs), which expressed typical undifferentiated markers and passed standard pluripotency assays. Genome-wide microarray analysis revealed that AD-iPSCs were highly similar to control hiPSCs and hESCs, albeit with some noticeable differences in few genes, viz.: DNAJC15, GRPR, NAIP and SNORD116-18. Seve...

Objective: To explore the diagnostic features and inheritance patterns of spinal muscular atrophy (SMA) in children at three tertiary care public hospitals. Study Design: Retrospective study. Setting: HITEC Institute Medical Sciences Taxila Cantt. Period: January 2022 to March 2022. Material & Methods: A retrospective review medical records past ten years from 2011 December 2020 hospitals w...

Kaempferol, a flavonoid, contains plethora of therapeutic properties and has demonstrated its efficacy against cancer. This study aims to unravel the molecular targets that are being modulated by kaempferol on HeLa cells. Various assays were performed, namely: MTT assay, flow cytometry analyze DNA content quantitate apoptosis. Quantitative PCR protein profiling performed evaluate manifestation ...

Werdnig-Hoffmann disease (WHD) is the most severe clinical type of spinal muscular atrophy characterized by loss of lower motor neurons and paralysis. We examined the hypothesis that disease pathogenesis is based on an inappropriate persistence of normally occurring motor neuron programmed cell death. The diagnosis of WHD was made on the basis of clinical findings, electromyoneurography, and bi...

Spinal muscular atrophy (SMA) type 2 is a motor neuron disease that leads to severe congenital muscle atrophy. The majority of adult patients are at risk of death due to respiratory failure. Here, we report on two patients with SMA type 2 who repeatedly developed bronchitis and pneumonia. The patient in Case 1 was a 48-year-old female lacking exon 7 of the survival motor neuron gene (SMN) 1. Th...

Most health care professionals now recognize a hospitalist as a physician who dedicates 25% or more of his or her time to the practice of inpatient medicine and who manages the care of hospitalized patients for primary care physicians [1,2]. The National Association of Inpatient Physicians (NAIP) estimates there are currently 3000 to 4000 practicing hospitalists in the United States; this numbe...

In contrast to agricultural settings, irrigation of residential properties in urban settings is typified by small and irregular areas, many untrained water users, limited end-use metering, differing groundcover. This makes analyzing patterns promote efficient use challenging. We explore the remote sensing tools data sets help characterize United States. Herein, we review available multispectral...

Abstract Background Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease representing the most prevalent monogenic cause of infant mortality. It results from loss SMN1 gene, but retention its paralog SMN2 whose copy number can modulate severity and guide therapeutic regimen. Methods For SMA molecular analysis, 236 unrelated Egyptian patients were enrolled at our institu...