Drug synthesis and discovery represents today one of the most rapidly evolving scientific areas. This is primarily due to the interdisciplinary collaboration between chemists, pharmacologists, molecular biologists, and biochemists. A direct implication of the developments in drug discovery is the need for novel drug delivery systems and devices. Considering the advances in engineering disciplin...

Acetalated dextran (Ac-DEX) is a pH-responsive derivative polymer. Ac-DEX and its functional derivatives have been formulated as nano- or microparticles for drug delivery applications in the biomedical field.

objective: pmbn, poly [2-methacryloyloxyethyl phosphoryl choline (mpc)-co-n- buthyl methacrylate (bma)-co-p-nitrophenyl- oxycrabonyl poly (ethylene glycol-methacrylate (meonp)], as a biocompatible ter-polymer is a unique polymer with wide range of application from drug delivery systems to scaffolds and biomedical devices. in this research, monomer of p- nitrophenyl- oxycarbonyl poly (ethylene g...

Micro/nanoparticles could cause adverse effects on cardiovascular system and increase the risk for cardiovascular disease-related events. Nanoparticles prepared from poly(ethylene glycol) (PEG)-b-poly(ε-caprolactone) (PCL), namely PEG-b-PCL, a widely studied biodegradable copolymer, are promising carriers for the drug delivery systems. However, it is unknown whether polymeric PEG-b-PCL nano-mic...

Rosuvastatin is a lipid lowering agent, which has low solubility and low bioavailability of 20% with oral administration. Therefore the present study was undertaken to improve solubility and bioavailability of Rosuvastatin by formulating it into Nano structured lipid carriers (NLCs) by using stearic acid and Compritol ATO 888 as solid-lipid, Oleic acid as liquid-lipid and Poloxamer 188 as a sur...

AIM The aim of this study was to design multi-walled carbon nanotubes (MWCNTs) loaded with paclitaxel (PTX) anti-cancer drug and investigate its anti-cancerous efficacy of human gastric cancer. BACKGROUND Carbon nanotubes (CNTs) represent a novel nano-materials applied in various fields such as drug delivery due to their unique chemical properties and high drug loading. PATIENTS AND METHODS...

Although vaccines and antibiotics could kill or inhibit microbes, many infectious diseases remain difficult to treat because of acquired resistance and adverse side effects. Nano-carriers-based technology has made significant progress for a long time and is introducing a new paradigm in drug delivery. However, it still has some challenges like lack of specificity toward targeting the infectious...

Various types of nanoparticles, such as liposomes, polymeric micelles, dendrimers, superparamagnetic iron oxide crystals, and colloidal gold, have been employed in targeted therapies for cancer. Both passive and active targeting strategies can be utilized for nano-drug delivery. Passive targeting is based on the enhanced permeability and retention (EPR) effect of the vasculature surrounding tum...

Crystal-like structures at nano and micron scales have promise for purification and confined reactions, and as starting points for fabricating highly ordered crystals for protein engineering and drug discovery applications. However, developing controlled crystallization techniques from batch processes remain challenging. We show that neutrally charged nanoscale spherical micelles from biocompat...