Diblock copolymer nanoparticles encapsulating a paclitaxel prodrug, Propac 7, have been used to demonstrate the usefulness of a nonmetabolizable radioactive marker, cholesteryl hexadecyl ether (CHE), to evaluate nanoparticle formulation variables. Since CHE did not exchange out of the nanoparticles, the rate of clearance of the CHE could be used as an indicator of nanoparticle stability in vivo...

We describe polymer-stabilized droplets capable of recognizing and picking up nanoparticles from substrates in experiments designed for transporting hydroxyapatite nanoparticles that represent the principal elemental composition of bone. Our experiments, which are inspired by cells that carry out materials transport in vivo, used oil-in-water droplets that traverse a nanoparticle-coated substra...

We successfully prepared Au-nanoparticle-decorated ZnS (ZnS-Au) spheres by sputtering Au ultrathin films on surfaces of hydrothermally synthesized ZnS spheres and subsequently postannealed the samples in a high-vacuum atmosphere. The Au nanoparticles were distributed on ZnS surfaces without substantial aggregation. The Au nanoparticle diameter range was 5 to 10 nm. Structural information showed...

Measuring electrochemical activities of nanomaterials is critical for creating novel catalysts, for developing ultrasensitive sensors, and for understanding fundamental nanoelectrochemistry. However, traditional electrochemical methods measure a large number of nanoparticles, which wash out the properties of individual nanoparticles. We report here a study of transient electrochemical oxidation...

In this review, we describe the contribution of peptides to the biomedical applications of metallic nanoparticles. We also discuss strategies for the preparation of peptide-nanoparticle conjugates and the synthesis of the peptides and metallic nanoparticles. An overview of the techniques used for the characterization of the conjugates is also provided. Mainly for biomedical purposes, metallic n...

Supplementary Figure S1: Antenna enhancement for another antenna-particle pair: Same graph as in Fig.4 of the main text, but for another antenna-nanoparticle pair. The black curve shows the differential pump-probe spectrum of a single nanoparticle with 50 nm in diameter. As predicted this signal is stronger and also red shifted by about ∆λ = 20 nm compared to the single 40 nm nanoparticle shown...

Molecular dynamics (MD) simulation was used to explore the liquid-solid (crystal) phase change of a ceria nanoparticle. The simulations reveal that the crystalline seed, which spontaneously evolves and nucleates crystallisation, is a liquid rather than a solid. Evidence supporting this concept includes: (a) only 3% of the total latent heat of solidification had been liberated after 25% of the n...

Gold nanoparticle assemblies possess diverse application potential, ranging from industrial nanotechnology to medical biotechnology. Because the structures and properties of assemblies are directly affected by the stabilization mechanism between the organic molecules serving as protecting ligands and the gold nanoparticle surface, it is crucial to find and investigate new stabilization mechanis...

Direct in vivo administration of messenger RNA (mRNA) delivered in both naked and nanoparticle formats are actively investigated because the use of dendritic cells transfected ex vivo with mRNA for cancer therapy is expensive and needs significant infrastructure. Notably, intravenous and subcutaneous injections are the only routes of administration tested for mRNA nanoparticle tumor vaccination...

Physicochemical analyses of Au nanoparticle monolayer formation on a glass surface functionalized with 3-aminopropyltrimethoxysilane (APTMS) and ethyltrimethoxysilane (ETMS) were performed for fabricating a nanoarchitecture of metal nanoparticles using self-assembly. The Au nanoparticle surface density on the functionalized glass surface correlated linearly with the optical response because of ...