the oudna field part of the offshore northeastern tunisia, straddles between two structural domains, the tunisian atlas to the north and the pelagian sea to the south. the study of this field has confirmed adequate petroleum system in fahdene formations (albian-cenomanian) and birsa (serravallian) resulting from the combination of several sedimentary, tectonic and thermal factors. to do this, w...

Out of 360 lungs or lobes surgically removed, 13 non neoplastic specimens and 16 neuroendocrine (NE) tumours are investigated with immunohistochemical methods, in order to evaluate the presence of NE structures in normal and pathological human lungs. The markers used are neuron specific enolase (NSE), chromogranin (CG) and the 80 kd antigen (80 kdAg) of NE secretory granules detected by the new...

Background Neonatal encephalopathy (NE) is a leading cause of child mortality and longer-term impairment. Infection can sensitize the newborn brain to injury; however, the role of group B streptococcal (GBS) disease has not been reviewed. This paper is the ninth in an 11-article series estimating the burden of GBS disease; here we aim to assess the proportion of GBS in NE cases. Methods We co...

We have examined the impact of partial injury to central noradrenergic terminals on whole tissue norepinephrine (NE) content in hippocampus and on the concentration of NE and 3,4-dihydroxyphenylacetic acid in extracellular fluid of that structure (using microdialysis perfusion). Partial unilateral depletions of hippocampal tissue NE content were produced by administration of 6-hydroxydopamine (...

Ligand binding and conformational changes that accompany signaling from G protein–coupled receptors (GPCRs) have mostly focused on the role of transmembrane helices and intracellular loop regions. However, recent studies, including several GPCRs cocrystallized with bound ligands, suggest that the extracellular surface (ECS) of GPCRs plays an important role in ligand recognition, selectivity, an...

Extracellular proteolysis of basement membranes and matrix is required for leukocyte diapedesis and migration to the inflammatory focus. Neutrophil elastase (NE) and matrix metalloproteinases (MMPs) are among the enzymes involved in these processes, as shown in mice genetically deprived of such enzymes. However, studies with MMP-9(-/-) mice revealed that albeit neutrophil influx is impaired ini...

Chemosensitive neurons in the retrotrapezoid nucleus (RTN) regulate breathing in response to CO2/H(+) changes and serve as an integration center for other autonomic centers, including brain stem noradrenergic neurons. Norepinephrine (NE) contributes to respiratory control and chemoreception, and, since disruption of NE signaling may contribute to several breathing disorders, we sought to charac...

Exposure to lower body negative pressure (LBNP) leads to an increased activation of the sympathetic nervous system (SNS) and an increase in muscle sympathetic nerve activity (MSNA). In this study, we examined the relationship between MSNA and interstitial norepinephrine (NE(i)) concentrations during LBNP. Twelve healthy volunteers were studied (26 +/- 6 yr). Simultaneous MSNA and microdialysis ...

Neutrophil elastase (NE) is an early myeloid-specific serine protease, which is predominantly produced by promyelocytes. A previous study demonstrated that NE has an important role in the development of acute promyelocytic leukemia (APL). The process of APL was shown to be accelerated in animals that expressed abundant NE, whereas NE‑deficient mice were protected from APL development; thus sugg...

Background—Chronic excessive norepinephrine (NE) causes cardiac sympathetic nerve terminal abnormalities, myocardial b-adrenergic receptor downregulation, and b-adrenergic subsensitivity. The present study was carried out to determine whether these changes could be prevented by antioxidants. Methods and Results—Ferrets were administered either NE (1.33 mg/d) or vehicle by use of subcutaneous pe...