A morphometric procedure yielding dependable quantita tive data on structural components of tumors was devised. Semiquantitative data on necrobiosis, karyorrhexis, and infiltrating inflammatory cells were also obtained. Sections of tumor cut in three mutually perpendicular directions revealed minor quantitative intratumor variation for smallcell and epidermoid carcinoma but greater ones for ade...

Scleredema diabeticorum is a rare complication of diabetes, characterized by diffuse induration of the skin over the neck, shoulders, and upper trunk and arms, progressively leading to limited upper body motility and impaired respiratory function (1). Etiology is unknown, and histopathological findings include thickened dermis with abundant mucin deposition among large collagen bundles. No trea...

A skin lesion previously unassociated with Crohn's disease is described. Although superficially resembling erythema nodosum it runs a different clinical course and has different histological appearances, the central feature being necrobiotic collagen. The term ;nodular necrobiosis' is suggested.

Monocytic sarcoma is a neoplasm of immature monocytes involving any extramedullary site such as skin. The definite diagnosis is important for adequate therapy, which is often delayed becauseof misdiagnosis. We report a 51-Year-old diabetic woman who presented with several erythematous itchy papules and plaques on her s...

an admirably clear description of the skin lesions in Xanthoma Diabeticorum, that it still remains unsurpassed. In describing the skin lesion of their diabetic patient, the authors wrote: ' An eruption somewhat suddenly appeared on the arms, at first apparently of a lichenous character. In the course of 10 days, it had extended over the arms, legs and trunk, both anteriorly and posteriorly, and...