This study aimed to evaluate factors associated with significant liver histological changes. Liver biopsies from 157 CHB patients were retrospectively analyzed. Only ALB was significantly correlated with advanced liver necroinflammatory (P = 0.001). Age, ALB, GLOB, AST, PLT, and PT were independent predictors of significant fibrosis (P = 0.002, P < 0.001, P = 0.001, P = 0.048, P < 0.001, and P ...

Nonalcoholic fatty liver disease (NAFLD) is present in up to one third of the general population and in the majority of patients with metabolic risk factors such as obesity and diabetes. Insulin resistance is a key pathogenic factor resulting in hepatic fat accumulation. Recent evidence demonstrates NAFLD in turn, exacerbates hepatic insulin resistance and often precedes glucose intolerance. On...

Hepatitis B virus (HBV) is a persistent pathogen that causes acute and chronic necroinflammatory liver disease and is attributable to ~1 million deaths per year. In the present study, a conventional murine model was introduced based on the hydrodynamic injection of engineered replication‑competent HBV DNA into the tail veins of C57BL/6 mice. In a previous study, nine in‑frame ATG (start) codons...

hronic infection with hepatitis B virus (CHB) affects as many s 350–400 million people worldwide and 93 million people n China.1 Moreover, elderly patients with CHB are increasing. ence, the treatment of elderly patients with CHB is an imporant issue. However, to our knowledge, there is no report about he efficacy of Entecavir (ETV) treatment on elderly patients ≥60 years) with CHB. A retrospec...

objective(s) the aim of this study was to evaluate antioxidant and hair growth activities of buxus wallichiana baill (buxaceae). materials and methods petroleum ether, chloroform, methanol and aqueous extracts of buxus wallichiana subjected to antioxidant activity by; 2, 2-diphenyl-1-picryl hydrazyl and nitric oxide methods. methanol extract of buxus wallichiana at 50, 100 mg/kg, ointment of me...

conclusions p. spinosa ethanol extract can be used as a mouthwash for treatment of the oral infections. more clinical and toxicological studies are required for providing its efficacy. results p. spinosa ethanol extract with higher-level phenolic and flavonoid contents showed the highest antioxidant and antimicrobial effects, in comparison with the other extracts. bacillus sp. and streptococcus...

Semiparametric hazard function regression models are among the well studied risk models in survival analysis. The Cox proportional hazards model has been a popular choice in modelling data from epidemiological settings. The Cox-Aalen model is one of the tools for handling the problem of non-proportional effects in the Cox model. We show an application on Piedmont cancer registry data. We initia...

background hepatic fibrosis is a typical complication of chronic liver diseases resulting in cirrhosis that remains a major public health problem worldwide. liver biopsy is currently the gold standard for diagnosing and staging hepatic fibrosis. percutaneous liver biopsy; however, is an invasive procedure with risks of complications. therefore, there is need for alternative non-invasive techniq...

IntroductionHeart transplantation (HT) is a viable, life-prolonging therapy for patients with severe cardiac amyloidosis. Unique amyloid-related pathology may complicate their care. We present case of rare manifestation amyloidosis complicating post-HT course.Case ReportA 51-year-old female AL (treated daratumumab, cyclophosphamide, bortezomib, and dexamethasone) chronic kidney disease was tran...

BACKGROUND/AIMS Beta blockers can inhibit tumor growth and metastases, while necroinflammation can enhance these tumor properties. The aim of this study was to determine whether beta blockers and necroinflammatory disease predict tumor recurrence and/or overall survival following potentially curative therapeutic interventions for patients with hepatocellular carcinoma (HCC). METHODOLOGY The m...