Neoadjuvant cisplatin-based chemotherapy has been widely used in the last decade for organ preservation or unresectable disease in advanced stage head and neck cancer. We examined the expression of a series of tumor markers that have been associated with chemotherapy resistance in pretreatment biopsies from 68 patients who received cisplatin-based neoadjuvant chemotherapy at either of two insti...

The purpose of this study is to evaluate the accuracy of mammography, ultrasonography, and contrast-enhanced magnetic resonance imaging for the diagnosis of intraductal spread of breast cancer following preoperative neoadjuvant chemotherapy. We evaluated a total of 168 areas of normal breast tissue outside the mass in 42 consecutive female patients with breast cancer using each imaging modality...

In Western countries, the standard treatment for locally advanced rectal cancer is preoperative chemoradiotherapy followed by total mesorectal excision. However, in Japan, the treatment results without preoperative chemoradiotherapy are by no means inferior; therefore, extrapolation of the results of preoperative treatment in Western countries to Japan is controversial. We consider that surviva...

BACKGROUND Aim of the study was to assess the value of scintimammography using Tc-99m sestamibi in the evaluation of tumor response to neoadjuvant chemotherapy. MATERIAL ANS METHODS: Results were calculated for 9 patients undergoing neoadjuvant chemotherapy. Scintimammography using 740 MBq Tc-99m sestamibi was performed before, during and after chemotherapy, and sestamibi uptake was scored visu...

Neoadjuvant radio(chemo)therapy is increasingly used in rectal cancer and induces a number of morphologic changes that affect prognostication after curative surgery, thereby creating new challenges for surgical pathologists, particularly in evaluating morphologic changes and tumour response to preoperative treatment. Surgical pathologists play an important role in determining the many facets of...

This integrative literature review had the objective of analyzing research on the occurrence of immediate transfusion incidents and implemented hemovigilance actions. Data were obtained through database searches of LILACS, MEDLINE and PubMed, for the period of 1980 to 2009, in the Portuguese, English and Spanish languages. We identified 1382 articles, of which 29 met the established inclusion c...

Objective: To determine the frequency and specificity of erythrocyte alloimmunization in patients treated by hemotherapy at University Hospital Professor Alberto Antunes - UFAL, Maceió-Alagoas, period 2013-2018. Methods: Retrospective analysis all patient records with request for red blood cell concentrate (RBC) a positive antibody test. Results: The incidence was higher women n=144 (80.45%) th...

Controversy exist regarding the potential benefit of the neoadjuvant approach to pancreatic cancer as limited retrospective data exists comparing pre- with post-operative chemoradiation. The optimal treatment approach remains unclear as we await prospective randomized clinical trials evaluating the hypothesized benefit of the neoadjuvant therapy for resectable pancreatic cancer and as there has...

Neoadjuvant therapy is a well-established approach for the treatment of locally advanced or inflammatory breast cancer (BC) and has been increasingly used in recent years not only as a management strategy but also as a research tool. Recently, nanoparticle albumin-bound paclitaxel (nab-paclitaxel)/trastuzumab combinations have been associated with promising activity in different clinical settin...

Assessment of respectability may be regarded as a key component esophageal cancer treatment. Neoadjuvant therapies considered particularly in the setting locally advanced cancer. While surgery alone adequate for selected patients, incorporation neoadjuvant or adjuvant therapeutic strategies with respect to patient, tumor, and treatment characteristics. In this study, we focused on tumor size ch...