With improved obstetrical management and evidence-based use of intrapartum antimicrobial therapy, early-onset neonatal sepsis is becoming less frequent. However, early-onset sepsis remains one of the most common causes of neonatal morbidity and mortality in the preterm population. The identification of neonates at risk for early-onset sepsis is frequently based on a constellation of perinatal r...

BACKGROUND Sepsis in neonates hospitalized in the neonatal intensive care unit is a global problem and is a significant contributor to morbidity and mortality. Neutrophil surface CD64, the high-affinity Fc receptor, is quantitatively up-regulated during infection and sepsis. OBJECTIVE Our goal in this prospective study was to measure the neutrophil CD64 in blood as an adjunct to our previousl...

Early diagnosis of neonatal septicemia is difficult due to lack of specific clinical and laboratory findings. Blood culture is considered gold standard for the diagnosis, but is very time consuming. Hence most of the paediatricians administer antibiotics at the least suspicion of sepsis. To overcome this, several rapid haematological tests have been evaluated for their usefulness in rapid diagn...

AIM To determine serum IL-1beta, IL-6, IL-8, and TNF-alpha levels in neonatal sepsis at the time of diagnosis and after therapy, and to show the meaningful on the follow up. METHODS This prospective study was performed on newborns who were hospitalized for neonatal sepsis and who were classified as culture-proven sepsis (n=12), as culture-negative sepsis (n=21), and as healthy newborns (n=17)...

With improved obstetrical management and evidence-based use of intrapartum antimicrobial therapy, early-onset neonatal sepsis is becoming less frequent. However, early-onset sepsis remains one of the most common causes of neonatal morbidity and mortality in the preterm population. The identification of neonates at risk for early-onset sepsis is frequently based on a constellation of perinatal r...

Background: It has recently been suggested that serum procalcitonin (PCT) is of value in the diagnosis of neonatal sepsis, with varying results. The aim of this prospective multicenter study was to assess the usefulness of PCT as a marker of neonatal sepsis of nosocomial origin. Methods: One hundred infants aged between 4 and 28 days of life admitted to the Neonatology Services of 13 acute-care...

BACKGROUND Long-term, sustainable programs to address high incidence and death rates from neonatal infections are required for improving child survival. There is an urgent need to define the role of community-based management for neonates with serious bacterial infections--both at home and at first-level facilities. METHODS We reviewed available evidence for community-based antibiotic managem...

objective the aim of the present study was to evaluate the etiology and frequency of neonatal seizure in hospitalized neonates. materials and methods in this descriptive, cross-sectional study, we evaluated 1295 neonates with seizures admitted to neonatal and nicu wards in our center. data was collected on age, sex, birth weight, serum levels of calcium, glucose, and sodium, ct scan findings, h...