BACKGROUND The COL4A3-/- mouse serves as animal model for progressive renal fibrosis. Using this animal model, the present study investigates the nephroprotective effects of Paricalcitol versus Calcitriol alone and on top of ACE-inhibitor therapy. METHODS Eighty six mice were divided into six groups: (PC) with Paricalcitol 0.1 mcg/kg, (CA) Calcitriol 0.03 mcg/kg (dose equipotent), (PLAC) vehi...

Dong quai has been used for thousands of years in traditional Chinese, Korean, and Japanese medicine. Dong quai is marketed in the United States as a dietary supplement. It has been used to treat a variety of ailments including, dehydration, lumbago, hypertonia, nervous disorders, menopausal symptoms, neuralgia, angina, insomnia, and arthritis. Overall, human studies suggest that there is littl...

Abstract Background and Aims The most common effect of renal disease in the world is diabetic nephropathy (DN). Dipeptidyl peptidase–IV (DPP-IV) enzyme abundant present kidney, which increased nephropathy. A novel approach to treat type 2 diabetes mellitus (T2DM) along with DN, based on incretin hormones: glucagon-like peptide-1 (GLP-1) regulated by DPP-IV. We hypothesized that DPP-IV inhibitor...

This study was carried out to evaluate the protective effects of polyherbal extract against gentamicin induced renal injury in rats. 36 male Wistar rats were divided into six groups. Gentamicin administered (100 mg/kg, intraperitoneally for 10 d) all groups except normal control group. Polyherbal three (gentamicin+polyherbal 100 gentamicin+polyherbal 200 mg/kg and 300 mg/kg) at 100, body weight...