BACKGROUND Two-stage facial reanimation procedures with a cross-facial nerve graft often have unsatisfactory results in the older patient. Although the cause of result variability is likely multifactorial, some studies suggest that increased donor nerve axonal load improves function of a free muscle transfer after a cross-facial nerve graft. This study attempts to characterize the relationship ...

In the present study, we compared the effects of implanting peripheral sensory nerve and motor nerve on motoneuron survival and regeneration after spinal root avulsion in adult rats. Our results showed that 116% more motoneurons regenerated axons into the motor than the sensory nerve graft and 59% of motoneurons survived in the motor nerve-implanted group compared to 48% in the sensory nerve-im...

UNLABELLED Autogenous bone graft is the ideal substrate for primary and revisional foot and ankle surgery. The distal medial tibia is an easily accessible site that provides both cancellous and corticocancellous autograft. Thirty cases of distal tibial bone graft with a minimum follow-up of 1 year are presented. There was an 86% union rate, and there were no stress fractures, persistent pain, o...

The goal of this study was to determine the functional axonal anatomy of a termino-lateral neurorrhaphy (TLN). We hypothesize that axons populating a TLN must relinquish functional connections with their original targets prior to establishing new connections via the TLN. Two-month-old F344 rats underwent a TLN between the left peroneal nerve and a nerve graft tunneled to the contralateral hindl...

The adult CNS is an inhibitory environment for axon outgrowth, severely limiting recovery from traumatic injury. This limitation is due, in part, to endogenous axon regeneration inhibitors (ARIs) that accumulate at CNS injury sites. ARIs include myelin-associated glycoprotein, Nogo, oligodendrocyte-myelin glycoprotein, and chondroitin sulfate proteoglycans (CSPGs). Some ARIs bind to specific re...

ObjectiveAdipose tissue is an appropriate source for isolation of cells with stem-cell–like properties. In the present long-term study, the effects of the omental adipose-derived nucleated cells (OADNCs) fraction were compared to those of the undifferentiated cultured bone marrow stromal cells (BMSCs) on sciatic nerve regeneration. DesignExperimental in vivo study. AnimalsFifty male White Albin...

95 Hyun Gu Kang, MD Myong Chul Park, MD, PhD Dong Ha Park, MD Department of Plastic and Reconstructive Surgery Ajou University Hospital Gyeonggi-do, Korea Sir: F synkinesis is an abnormal involuntary movement of one set of facial muscles accompanying a voluntary movement of a different facial muscle. It is not uncommon for patients with longstanding facial paralysis to present with abnormal, in...

Fetal monoaminergic tissue was examined for its capacity to reinnervate rat striatum and to study the function of the graft. When grafting human fetal mesencephalic tissue to dopamine depleted striatum, a reduction in apomorphine rotational behavior was well correlated with the time outgrowing fibers were detected with tyrosine hydroxylase (TH) immunohistochemistry. Cell migration from graft to...

Because the vagus nerve is implicated in control of inflammation, we investigated if brain death (BD) causes impairment of the parasympathetic nervous system, thereby contributing to inflammation. BD was induced in rats. Anaesthetised ventilated rats (NBD) served as control. Heart rate variability (HRV) was assessed by ECG. The vagus nerve was electrically stimulated (BD + STIM) during BD. Inte...

There are numerous factors that affect the success of peripheral nerve grafting. Among these are (1) the type of injury to the nerve; (2) the degree of damage to the sur rounding tissue and its complications; (3) the general condition of the patient; (4) the age of the patient; (5) the size, level and location of the nerve defect; (6) the local nutrition and the amount of scar in and around the...