PURPOSE Determining the relationships between phenotype and genotype of many disorders can improve clinical diagnoses, identify disease mechanisms, and enhance therapy. Most genetic disorders result from interaction of many genes that obscure the discovery of such relationships. The hypothesis for this study was that image analysis has the potential to enable formalized discovery of new visible...

PURPOSE To develop a systematic method for identifying and grading age-related macular degeneration (ARMD) in human donor eyes, postmortem fundus appearance was compared with histopathologic assessment in eyes with a spectrum of age-related macular change. METHODS Eyes without grossly visible, late ARMD were obtained from 8 cancer patients and 26 donors older than 50 years. Postmortem fundus ...

AIM To determine the sub-macular Bruch's membrane (BrM) macrophage count and the choroidal and BrM macrophage immunophenotype in normal eyes and in eyes with early and advanced age-related macular degeneration (AMD). METHODS BrM macrophages were counted in 125 human eyes (normal, normal aged, early AMD and geographical atrophy), and CD68 and inducible nitric oxide synthase (iNOS) immunohistoc...

AIMS To examine a large family with an autosomal dominant fundus dystrophy and to investigate whether or not mutations in TIMP-3 gene were involved. METHODS A large family of 58 individuals with an autosomal dominant fundus dystrophy was examined ophthalmologically. A DNA linkage analysis in the 22q12.1-q13.2 region was performed. The TIMP-3 gene was screened for mutations in all five exons. ...

Biometric system is a pattern-recognition system that recognizes a person based on the personal physiological or behavioural characteristics that the person possesses. Human retina, one source of biometric provides the most reliable and with the emerging potentials of automated image processing a highly secure means of authentication is possible. The proposed system describes the development of...

Regional changes in retinal blood flow following inferior and subsequent superior argon laser half fundus photocoagulation treatment were measured in six diabetic patients with advanced retinopathy. Centreline blood velocity, vessel diameter, and blood flow in major inferior and superior temporal retinal arteries were measured at baseline and following each treatment using the bidirectional las...

AIM To study the passive and active transport of fluorescein across the blood-retina barrier in early age related maculopathy (ARM) (soft drusen > 63 microm, hyperpigmentation and/or hypopigmentation in patients above 50 years of age). METHODS 15 patients and 10 healthy subjects were included. Morphological changes were graded from 30 degrees fundus photographs using a simplified version of t...

Diabetic Retinopathy (DR) is a common eye disease that affects over 3 million people annually. People with diabetes are more prone to suffer from Retinopathy. This condition can cause blurring of vision and blindness. Early detection treatment the most effective ways manage Due huge number diabetic patients need for accurate automatic diagnosis, development deep neural networks has been acknowl...

Pseudoxanthoma elasticum (PXE) is a genetic multisystemic disorder affecting the skin, eyes and cardiovascular system. Basic fundoscopic findings in PXE result from Bruch's membrane involvement. The most important fundoscopic findings are angioid streaks. Other significant ocular findings are peau d'orange appearance, optic disc drusen, pattern dystrophy-like macular appearance, comet lesions, ...