Endocrine therapy is the treatment of choice in hormone receptor-positive breast cancer. However, the effectiveness of these agents is limited by the development of drug resistance, ultimately leading to disease progression and patient mortality. Whilst pre-clinical cell models of acquired endocrine resistance have demonstrated a role for altered growth factor signalling in the development of a...

The notion of a tumour in the brain is a most terrifying prospect for most individuals and many physicians. Yet brain tumour is the second most common form of malignancy in childhood, and accounts for the 3rd or 4th most frequent cause of cancer death among middle-aged adults. More optimal control of primary malignancies has also contributed to a phenomenal increase in the incidence of metastat...

Abstract AIMS 5-ALA (Gliolan©) is a valuable surgical tool used predominantly in high grade tumours, which utilises tissue fluorescence to improve the visualisation of brain-tumour interface. This ensures safe maximal resection, while preserving healthy brain. While Gliolan© use low tumours has previously been reported with variable results, reports its and success context SEGA are extremely ra...