Since the outbreak of the enterovirus 71 (EV71) infection in Malaysia in 1997, large epidemics of EV71 have occurred in the Asia-Pacific region. Many children and infants have died from serious neurological complications during these epidemics, and EV71 infection has become a serious public health problem in these areas. EV71 infection causes hand, foot and mouth disease (HFMD) in children, and...

1. Chen QY, Lan Ms, she JX, Maclaren NK. the gene responsible for autoimmune polyglandular syndrome type 1 maps to chromosome 21q22.3 in us patients. J Autoimmun 1998;11:177-183. 2. Halonen M, Eskelin P, Myhre Ag, et al. AIRE mutation and human leukocyte antigen genotypes as determinants of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy phenotype. J Clin Endocrinol Metab 199...

Solid organ transplantation (SOT) is the preferred treatment for an expanding range of conditions whose successful therapy has produced a growing population of chronically immunosuppressed patients with potential neurological problems. While the spectrum of neurological complications varies with the type of organ transplanted, the indication for the procedure, and the intensity of long-term req...

Although a few textbooks persist in describing separately 'Schonlein's purpura' and 'Henoch's purpura' the recognition of the Schonlein-Henoch syndrome as a disease entity cannot now be disputed. The characteristic exanthem, the frequent occurrence of arthritis and intestinal symptoms, together with the possibility of renal damage, are well known. Serious neurological complications of this cond...

A 69-year-old male cardiac transplant recipient with end-stage renal disease secondary to cyclosporin toxicity, presented with a painful swollen right brachial AVF following difficult cannulations over several consecutive dialysis sessions. On inspection there was a tender soft tissue swelling overlying the fistula, but a thrill was still palpable. Neurological examination revealed weakness of ...

Neurological complications whether due to the uremic state or its treatment, contribute largely to the morbidity and mortality in patients with renal failure. Despite continuous therapeutic advances, many neurological complications of uremia, like uremic encephalopathy, atherosclerosis, neuropathy and myopathy fail to fully respond to dialysis. Moreover, dialytic therapy or kidney transplantati...

Cardio-facio-cutaneous syndrome (CFC) is a multiple congenital anomaly disorder characterized by craniofacial dysmorphia, ectodermal abnormalities, congenital heart defects, and developmental and growth delay. Neurological complications associated with CFC remain to be clearly defined. Recent discovery of causative mutations in genes of the MAPK pathway (BRAF, MEK1, and MEK2) now permit accurat...

Thematic Units Arrhythmias and Electrophysiology Basic Research Bioengineering and Medical Informatics Cardiac Surgical Intensive Care Cardiomyopathies Cardiovascular Nursing Cardiovascular Pharmacology Cardiovascular Surgery Chagas Disease Echocardiography Epidemiology and Cardiovascular Prevention Heart Failure Hemodynamics Cardiovascular Interventions High Blood Pressure Ischemic Heart Disea...

The role played by congenital malformations of the skull and spine in the production of lesions of the central nervous system has been increasingly appreciated in recent years. In the skull premature synostosis of the sutures of the vault (craniostenosis) can lead to optic atrophy and symptoms of intracranial hypertension. Hydrocephalus and compression of the brain stem and upper cervical cord ...

BACKGROUND Neurological complications after lung transplantation are common. The full spectrum of neurological complications and their impact on clinical outcomes has not been extensively studied. METHODS We investigated the neurological incidence of complications, categorized according to whether they affected the central, peripheral or autonomic nervous systems, in a series of 109 patients ...