metabotropic glutamate receptors (mglurs) consist of a large family of g-protein coupled receptors that are critical for regulating normal neuronal function in the central nervous system. the wide distribution and diverse physiological roles of various mglur subtypes make them highly attractive targets for the treatment of a number of neurological and psychiatric disorders. the discovery of sub...

coenurosis is a disease of the central nervous system in sheep, caused by coenurus cerebralis , the larval stage of multiceps multiceps , which inhabits the small intestine of canidae. a case of regurgitations in a 2.5 month old lamb with acute coenurosis is being reported. the lamb was presented with a sudden onset of ataxia and re-gurgitations for 10 days. the post-mortem examination revealed...

AIM To describe the prevalence and types of neurological disease that occur in association with uveitis. METHODS Retrospective review of medical records of patients attending a tertiary referral uveitis service over a 15 year period. RESULTS Of 1450 patients with uveitis, 115 (7.9%) had neurological disease that was considered to be causally related to the eye inflammation. The most frequen...

Scientists, clinicians, administrators, individuals with spinal cord injury (SCI), and caregivers seek a common goal: to improve the outlook and general expectations of the adults and children living with neurologic injury. Important strides have already been accomplished; in fact, some have labeled the changes in neurologic rehabilitation a "paradigm shift." Not only do we recognize the potent...

A significant role of neurology for medicine and society is caused by severity of clinical presentations and consequences of the nervous system diseases, as well as by huge economic burden related to neurological pathology. The paper presents a review of the current state and prospects for the development of socially most important fields of modern neurology, among which one can list studies of...

OBJECTIVES To evaluate the presence of neurological soft signs (NSS) and to correlate them with the Wechsler Intelligence Scale for Children (WISC III) in patients with rolandic epilepsy (RE). METHODS Forty children and adolescents aged between 9 and 15 years were studied. They were divided into two groups: G1 - patients with RE (n=20) - and G2 - healthy controls without epilepsy (n=20). They...

OBJECTIVE Computation in nervous systems operates with different computational primitives, and on different hardware, than traditional digital computation and is thus subjected to different constraints from its digital counterpart regarding the use of physical resources such as time, space and energy. In an effort to better understand neural computation on a physical medium with similar spatiot...

It is commonly accepted that inefficient recruitment and inadequate retention continue to threaten the completion of clinical trials intended to reduce the public health burden of neurological disease. This article will discuss the scientific, economic, and ethical implications of failure to recruit and retain adequate samples in clinical trials, including the consequences of failing to recruit...