Currently, there are no drugs for the specific treatment of hypertensive retinal changes. The main therapy is a systemic disease – disease. Therefore, search ways pharmacological correction changes great interest. aim study: To evaluate possibility injuries with Semax in rat model neuroretinopathy. Materials and methods: was performed by injection N-nitro-L-arginine methyl ester (L-NAME) at dos...

Aging is related to several changes in metabolic rates and metabolism control unfolding at different level, from cell-autonomous dysfunctions to altered homeostatic manteinance of energy balance. The formers have been consistely linked to the dysfunction of mitochondria; on the other hand, the latter seems to be related to altered senstivity or function of hypothalamic nuclei. In normal aging, ...

Closed loop neuromodulation, where the stimulation is controlled autonomously based on physiological events, has been more effective than open loop techniques. In the few existing closed loop implementations which have a feedback, indirect non-neurophysiological biomarkers have been typically used (e.g. heart rate, stomach distension). Although these biomarkers enable automatic initiation of ne...

OBJECTIVE To determine the presence of gender neurometabolic differences in healthy men and women by multivoxel magnetic resonance spectroscopy (MRS). MATERIALS AND METHODS We performed multivoxel magnetic resonance imaging and spectroscopy in 50 healthy volunteers (27 women and 23 men) using 1.5T scanner. Spectra from 12 different voxels were obtained, covering frontal, paracentral, and pari...

Introduction: The endocannabinoid system (ECS) regulates functions throughout human physiology, including neuropsychiatric, cardiovascular, autonomic, metabolic, and inflammatory states. The complex cellular interactions regulated by the ECS suggest a potential for vascular disease and stroke prevention by augmenting central nervous and immune cell endocannabinoid signaling. Discussion: The end...

European Journal of NeurologyVolume 28, Issue 3 p. 733-734 EDITORIAL Hypomyelinating leukodystrophies in adults Fanny Mochel, Corresponding Author Mochel [email protected] AP-HP, Department Genetics, Reference Centers for Adult Neurometabolic Diseases and Leukodystrophies, Pitié-Salpêtrière University Hospital, Paris, France INSERM U 1127, CNRS UMR 7225, UPMC Univ Paris 06 S Institut du Cerv...

OBJECTIVE Methylmalonic acidemia is one of the inborn errors of metabolism resulting in the accumulation of acylcarnitine in blood and increased urinary methylmalonic acid excretion. This disorder can have symptoms, such as neurological and gastrointestinal manifestations, lethargy, and anorexia. MATERIALS & METHODS The patients who were diagnosed as methylmalonic acidemia in the Neurology De...