Mature retinal ganglion cells (RGCs) cannot regenerate injured axons because some neurite growth inhibitors, including the C-terminal of Nogo-A (Nogo66), myelin-associated glycoprotein (MAG) and Omgp, exert their effects on neuron regeneration through the Nogo receptor (NgR). In this study, the axonal regeneration of retinal ganglion cells (RGCs) after optic nerve (ON) crush was investigated bo...

INTRODUCTION: Injuries associated with peripheral nerve damage effect ~1 million patients per year. Damage to the peripheral nervous system can be extremely debilitating and result in loss of end organ function, coupled with poor neuron regeneration capacity [1]. Currently the treatment option for injuries are microsurgical and there are no drug therapies available to improve recovery. Pharmaco...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Li X, Yuan L, Wang J, et al. MiR-1b up-regulation inhibits rat neuron proliferation and regeneration yet promotes apoptosis via targeting KLF7. Folia Neuropathologica. 2021;59(1):67-80. doi:10.5114/fn.2021.105132. APA Li, X., Yuan, L., Wang, J., Zhang, Z., Fu, S., & S. (2021). Neuropathologica, 59(1), 67-80. https...

Agrin is a synapse-organizing molecule that mediates the nerve-induced aggregation of acetylcholine receptors (AChRs) and other postsynaptic components at the developing and regenerating vertebrate neuromuscular junctions. At the neuromuscular junction, three different cell types can express agrin, i.e., neuron, muscle, and Schwann cell. Several lines of evidence suggested that neuron-derived a...

The development of approaches to regenerate neuronal connections that are lost after nervous system injury or during disease has proven enormously challenging. In the mammalian CNS the problem appears to be (at least) twofold. First, local extrinsic cues potently suppress axon outgrowth. However, efforts to blunt growth inhibitory effects of these molecules have not resulted in widespread regro...

This study investigates the incorporation of hyaluronan (HA) binding peptides into poly(ethylene glycol) (PEG) hydrogels as a mechanism to bind and retain hyaluronan for applications in tissue engineering. The specificity of the peptide sequence (native RYPISRPRKRC vs non-native RPSRPRIRYKC), the role of basic amino acids, and specificity to hyaluronan over other GAGs in contributing to the pep...

Immobilized growth factors on tissue matrices play a critical role in controlling cell growth processes and cell morphology. We report a strategy for immobilizing growth factors on genetically engineered phage matrices for tissue regeneration. We modified M13 phages to express biotin-like peptides (HPQ) and/or integrin binding peptides (RGD) on their major and minor coat proteins. The resulting...

BACKGROUND Amyotrophic lateral sclerosis (ALS), the most frequent adult onset motor neuron disease, is associated with hypermetabolism linked to defects in muscle mitochondrial energy metabolism such as ATP depletion and increased oxygen consumption. It remains unknown whether muscle abnormalities in energy metabolism are causally involved in the destruction of neuromuscular junction (NMJ) and ...