F the many substances that have been found to be mutagenic several are 0 also carcinogenic and considerable evidence has been accumulating to indicate a relationship between these two properties. Nitrogen and sulfur mustards were shown by AUERBACH and ROBSON (1944) to be mutagenic for Drosophila, a finding which has been confirmed by DEMEREC (1947a,b), BURDETTE (1952) and others. Nitrogen musta...

Circadian rhythms are endogenous cellular patterns that associate multiple physiological and molecular functions with time. The Neurospora circadian system contains at least three oscillators: the FRQ/WC-dependent circadian oscillator (FWO), whose core components are the FRQ, WC-1, WC-2, FRH, and FWD-1 proteins; the WC-dependent circadian oscillator (WC-FLO); and one or more FRQ/ WC-independent...

The SET domain is an evolutionarily conserved domain found predominantly in histone methyltransferases (HMTs). The Neurospora crassa genome includes nine SET domain genes (set-1 through set-9) in addition to dim-5, which encodes a histone H3 lysine 9 HMT required for DNA methylation. We demonstrate that Neurospora set-2 encodes a histone H3 lysine 36 (K36) methyltransferase and that it is essen...

The mechanism of biosynthesis of the simpler aromatic compounds has been significantly clarified recently by the use of mutant strains of Neurospora (1) and Escherichia coli (2) and by the use of isotopic carbon (3-6). The evidence indicates that aromatization takes place via dehydroquinic acid, dehydroshikimic acid, and shikimic acid. Although the ultimate source of the carbon atoms of the aro...