Among the present classes of calcium channel blockers, dihydropyridine derivatives are widely used in the therapy of hypertension, angina pectoris and the other cardiovascular diseases. Since the prototype of dihydropyridine derivatives, nifedipine, does not have the optimum pharmacokinetic and pharmacodynamic characteristics, several attempts have been made to synthesize other drugs in this ...

Heterocyclic compounds containing a pyrimidine nucleus are of special interests due to their applications in medicinal chemistry as they are the basic skeleton of several bioactive compounds such as antifungal, antibacterial, antitumor and antitubercular. As a part of our research in the synthesis of pyrimidine derivatives containing biological activities, some new tetrahydropyrimidine derivati...

in this paper, a new identification of the lagrange multipliers by means of the sumudu transform, is employed to  btain a quick and accurate solution to the fractional black-scholes equation with the initial condition for a european option pricing problem. undoubtedly this model is the most well known model for pricing financial derivatives. the fractional derivatives is described in caputo sen...

Gaussian scale space permits one to compute image derivatives. The limitation to some finite order is not inherent in the paradigm itself (Gaussian blurred functions are always smooth), but is caused by the interplay of (at least) two external factors. One is the ratio of the Gaussian scale parameter versus the atomic scale that limits physically or perceptually meaningful sizes (e.g. pixel siz...

Two studies were performed to evaluate the effects of dried distillers grains with solubles (DDGS) on the lactational performance of dairy cows. The intent of experiment 1 was to evaluate the effects of feeding increasing concentrations of DDGS on the feed intake and production of Holstein dairy cows. Twenty multiparous Holstein cows averaging 76 +/- 24 d in milk and 638 +/- 68 kg of body weigh...

The title compound, C17H27O8P, was prepared by Michaelis-Arbuzov reaction of ethyl 2-bromo-2-(2,3,4-tri-meth-oxy-phen-yl)acetate and triethyl phosphite. Such compounds rarely crystallize, but single crystals were recovered after the initial oil was left for approximately 10 years. The bond angle of the sp (3)-hybridized C atom connecting the benzene derivative with the phospho unit is widened m...

Many metals or their complexes can catalyze the cyclotrimerization of alkynes to give benzene derivatives.1-9 Among these catalysts, palladium chloride10 and its bis(benzonitrile) complex11 are the most convenient. In these reactions, the yields of benzene derivatives generally depend on the substituents of alkynes. In the past 50 years, the regioand chemoselectivity for the cyclotrimerization ...