Most patients with advanced breast cancer (ABC) ultimately die due to disease progression. Consequently, treatments for ABC are predominantly palliative in nature and, therefore, the tolerability profile of a given treatment is particularly relevant in these patients. While cytotoxic chemotherapy and endocrine therapy exhibit efficacy in hormone-sensitive, advanced disease, it is endocrine ther...

In this paper, we propose new sequential methods for detecting port-scan attackers which routinely perform random “portscans” of IP addresses to find vulnerable servers to compromise. In addition to rigorously control the probability of falsely implicating benign remote hosts as malicious, our method performs significantly faster than other current solutions. Moreover, our method guarantees tha...

BACKGROUND Insufficient response to monotreatment for depression is a common phenomenon in clinical practice. Even so, evidence indicating how to proceed in such cases is sparse. METHODS This study looks at the second phase of a sequential treatment algorithm, in which 103 outpatients with moderately severe depression were initially randomized to either short-term supportive psychodynamic the...

IMPORTANCE OF THE FIELD Standard triple therapy (STT) is the most used treatment for Helicobater pylori infection. The prevalence of antibiotic resistance has increased substantially in recent years and there has been a corresponding decrease in efficacy. AREAS COVERED IN THIS REVIEW Bibliographical searches were performed in MEDLINE and international congresses up to 2009 for 'Helicobacter p...

Partial search methods like bitstate hashing, or supertrace, allow formal verification techniques to be applied to problems which normally could not be solved by exhaustive verification. A high coverage (defined as the percentage of the reachable states actually explored by the verifier) is important since the higher the coverage the lower the probability that a protocol error is not detected. ...