Adult stem cells reside in specialized microenvironments, called niches, that maintain stem cells in an undifferentiated and self-renewing state. Defining and understanding the mechanisms that restrict niche signaling exclusively to stem cells is crucial to determine how stem cells undergo self-renewal while their progeny, often located just one cell diameter away from the niche, differentiate....

Niche overlap is increasingly used as a way of measuring the intensity of interorganizational competition. This paper examines and compares various distance and cosine measures of niche overlap. The analysis in this paper shows that Euclidean distance applied to the raw data as well as to transformed data is not an appropriate measure of niche overlap. An alternative measure from the cosine fam...

Approximately 80% of prostate cancers exhibit some degree of bone metastasis. The role of the bone marrow and the hematopoietic stem cell (HSC) niche in attracting metastatic cells and maintaining dormancy of disseminated tumor cells (DTCs) is an increasingly important topic towards the development of novel prostate cancer therapies. This paper reviews aspects of the HSC niche that lead to pros...

Satellite cells are considered to be adult skeletal muscle stem cells. Their ability to regenerate large muscle defects is highly dependent on their specific niche. When these cells are cultured in vitro, the loss of this niche leads to a loss of proliferative capacity and defective regeneration when implanted back into a muscle defect. The most important aspects of the niche will be discussed-...

Spatio-temporal changes in the diet, niche breadth and niche overlap of two species of Characidium from three different sites along a Neotropical coastal stream were studied during a dry and rainy season. Seasonal changes were restricted to the occurrence of plant items in the stomach contents. The relative importance of food items in the diet of both species varied across sites, but Diptera, E...

The maintenance of the proliferative cell niche is critical to epithelial tissue morphology and function. In this paper we investigate how current modelling methods can result in erroneous loss cells from niche. Using an established model inter-follicular epidermis find there a limit densities that be maintained basal layer (the niche) if do not include additional mechanisms stop We suggest new...

A central issue in the study of organizations relates to the explanation of the genesis of organizational diversity. In this context, niche-width theory deals with the consequences for organizational form survival of intertemporal selection processes in industries that feature environmental variation over time. Drawing from evolutionary biology, the theory links environmental change patterns to...

The rate of environmental niche evolution describes the capability of species to explore the available environmental space and is known to vary among species owing to lineage-specific factors. Trophic specialization is a main force driving species evolution and is responsible for classical examples of adaptive radiations in fishes. We investigate the effect of trophic specialization on the rate...