The predominant exposure route for nickel compounds is by inhalation, and several studies have indicated the correlation between nickel exposure and respiratory cancers. The tumor-promoting effects of nickel compounds are thought to be associated with their transactivation of transcription factors. We have investigated the possible activation of activator protein-1 (AP-1) and nuclear factor KB ...

An occupational hygiene survey was made in 38 nickel plating shops in Finland and exposure to nickel was studied by means of biological measurements and, in three shops, by using air measurements. The average after-shift urinary nickel concentration of 163 workers was 0.16 mumol l.-1 (range 0.001-4.99 mumol l.-1). After the 1-5 week vacation the urinary nickel concentration was higher than the ...

A nickel sensitivity patch test was applied to 700 child dental patients, aged 5-12 years,from the Dental Clinic at the University of Western Ontario and nearby pediatric dental offices. Approximately one-half the children were known to have nickel-containing dental appliances. From a case history obtained from the paten ts, the history of the wearing of pierced earrings and other jewelry was a...

Nickel is an essential metal for Helicobacter pylori, as it is the co-factor of two enzymes crucial for colonization, urease and hydrogenase. Nickel is taken up by specific transporters and its intracellular homeostasis depends on nickel-binding proteins to avoid toxicity. Nickel trafficking is controlled by the Ni(II)-dependent transcriptional regulator NikR. In contrast to other NikR proteins...

Bacteria have evolved a number of tightly controlled import and export systems to maintain intracellular levels of the essential but potentially toxic metal nickel. Nickel homeostasis systems include the dedicated nickel uptake system nik found in Escherichia coli, a member of the ABC family of transporters, that involves a periplasmic nickel-binding protein, NikA. This is the initial nickel re...

Nickel is a virulence determinant for the human gastric pathogen Helicobacter pylori. Indeed, H. pylori possesses two nickel-enzymes that are essential for in vivo colonization, [NiFe] hydrogenase and urease, an abundant virulence factor that contains 24 nickel ions per active complex. Because of these two enzymes, survival of H. pylori relies on an important supply of nickel, implying a tight ...

Although nickel exposure results in allergic reactions, respiratory conditions, and cancer in humans and rodents, the ramifications of excess nickel in the environment for animal and human health remain largely undescribed. Nickel and other cationic metals travel through waterways and bind to soils and sediments. To evaluate the potential toxic effects of nickel at environmental contaminant lev...

In this research, polyvinylchloride based composite heterogeneous cation exchange membranes were prepared by the solution casting technique. Chitosan-co-iron nickel oxide nanoparticles were utilized as membrane surface modifier to improve the membranes electrochemical properties. The effect of additive nanoparticle concentration in the modifier solution on the properties of composite membranes ...

Release of nickel from nickel or nickel-plated metals, is often responsible for allergic contact dermatitis. However, the effect of nickel-bearing stainless steels is not weil known. ln this paper AISI 304, 316 and 430 type stainless steels, as weil as nickel and nickel-plated materials, are investigated. Three tests were carried out: electrochemical tests and leaching experiments in sodium chl...