Membrane vesicles (MVs) produced by Gram-negative bacteria are being explored for novel clinical applications due to their ability to deliver active molecules to distant host cells, where they can exert immunomodulatory properties. MVs released by the probiotic Escherichia coli Nissle 1917 (EcN) are good candidates for testing such applications. However, a drawback for such studies is the low l...

Hilbert's finitist program was not created at the beginning of the twenties solely to counteract Brouwer's intuitionism, but rather emerged out of broad philosophical reflections on the foundations of mathematics and out of detailed logical work; that is evident from notes of lecture courses that were given by Hilbert and prepared in collaboration with Bernays during the period from 1917 to 192...

Hilbert’s finitist programwasnot created at the beginningof the twenties solely to counteract Brouwer’s intuitionism, but rather emerged out of broad philosophical reflections on the foundations of mathematics and out of detailed logical work; that is evident from notes of lecture courses that were given by Hilbert and prepared in collaboration with Bernays during the period from 1917 to 1922. ...

Hyperammonemia associated with chronic liver disease (CLD) is implicated in the pathogenesis of hepatic encephalopathy (HE). The gut a major source ammonia production that contributes to hyperammonemia CLD and HE remains primary therapeutic target for lowering hyperammonemia. As an ammonia-lowering strategy, Escherichia coli Nissle 1917 bacterium was genetically modified consume convert arginin...