A series of tetrazole derivatives (3a-h) were synthesized and screened for antioxidant activity by nitric oxide free radical scavenging activity. All the synthesized compounds were structurally elucidated by spectral techniques such as IR, H NMR spectroscopy and mass spectrometry. The compounds 3b, 3d 3f and 3h exhibited promising antioxidant activities which were found to be comparable with st...

When deprived of trophic factors, the majority of cultured motor neurons undergo nitric oxide-dependent apoptosis. However, for reasons that have remained unclear, 30-50% of the motor neurons survive for several days without trophic factors. Here we hypothesize that the resistance of this motor neuron subpopulation to trophic factor deprivation can be attributed to diminished nitric oxide produ...

“Oxidative stress” underlies a number of ailments & lipid peroxidation (LPO) also has economic implications/safety concerns as it contributes to spoilage food products/cosmetics and pharmaceuticals. Antioxidants seem hold solutions for such problems. Culinary herbs based antioxidants are in demand be food, cosmetic or pharma industry. In pursuit finding safe present evaluation employing com...

Excess activation of glutamate receptors and production of free radicals including nitric oxide may result in severe and irreversible damage to the mammalian central nervous system (CNS), but endogenous defense systems that protect neurons from these insults are poorly understood. Here, we purified and isolated a neuroprotective substance, which has been named "serofendic acid," from a lipophil...

Orange (C. sinensis) peel flavonoids have antibacterial, antioxidant, anticancer, anti-inflammatory, and antiviral effects. However, there is a scarcity of information in the literature about orange peels flavonoids. So, we estimated phytochemicals hydro-methanolic extract C. sinensis were separated by Column chromatography confirmed with TLC HPLC. After that evaluated antimicrobial, antioxidan...

1. We describe a rapid and reliable technique for the assessment of basal nitric oxide release in clinical situations, using peripheral blood polymorphonuclear leucocytes isolated by a single-step density gradient procedure. The assay is based on the quantitative conversion of oxyhaemoglobin to methaemoglobin by nitric oxide. We have further examined the ability of these cells to respond to var...

Background: Resveratrol is a natural polyphe- nolic compound, synthesized by plants as a phytoalexin and protects against ultraviolet radiation and fungal infection. Nitric oxide is formed from L-arginine through nitric oxide synthases (NOS), a group of enzymes that structurally resemble cytochrome P-450 reductase. In females, circulating NO is increased during follicle development and decrease...

UNLABELLED The blood storage lesion involves morphological and biochemical changes of red blood cells (RBCs) that occur during storage. These include conversion of the biconcave disc morphology to a spherical one, decreased mean corpuscular hemoglobin concentration, varied mean corpuscular volume, reduced integrity of the erythrocyte membrane with formation of microparticles, and increased cell...

Background & Aim:Oxidative stresses caused by free radicals are known to promote many diseases such as inflammation and cancer; therefore, any plant product that can inhibit free radical production can play an important role in preventing diseases. We aimed to compare the fracture rate and the scavenging activity of free radicals, and the antioxidant composition of rol...