نتایج جستجو برای: nitroso compound
تعداد نتایج: 130138 فیلتر نتایج به سال:
Ten carcinogenic V-niiroso compounds were assayed for DNA-damaging activity in primary cultures of human and rat hepatocytes. DNA fragmentation was measured by the alkaline elution technique, and un scheduled DNA synthesis by quantitative autoradiography. Positive doserelated responses in the range of subtoxic concentrations indicated were obtained in cells of both species with /V-nitrosodiethy...
Turtles of the genus Trachemys show a remarkable ability to survive prolonged anoxia. This is achieved by a strong metabolic depression, redistribution of blood flow and high levels of antioxidant defence. To understand whether nitric oxide (NO), a major regulator of vasodilatation and oxygen consumption, may be involved in the adaptive response of Trachemys to anoxia, we measured NO metabolite...
Purpose:PARP inhibitors are beingdeveloped as therapeutic agents for cancer.More than six compounds have entered clinical trials. The majority of these compounds are b-nicotinamide adenine dinucleotide (NADþ)-competitive inhibitors. One exception is iniparib, which has been proposed to be a noncompetitive PARP inhibitor. In this study, we compare the biologic activities of two different structu...
Ten carcinogenic V-niiroso compounds were assayed for DNA-damaging activity in primary cultures of human and rat hepatocytes. DNA fragmentation was measured by the alkaline elution technique, and un scheduled DNA synthesis by quantitative autoradiography. Positive doserelated responses in the range of subtoxic concentrations indicated were obtained in cells of both species with /V-nitrosodiethy...
1- in a search directed to the reaction of compound)23(the cycloaddition reaction of 1,3- diphenylisobenzofurane)14(with p-benzoquinone)19(,followed by addition of cyclopentadiene was carried out.the specific spacial stracture of its ir,nmr,mass spectra. 2- in another attempt the kinetic stability and behavior of compounds)20(and)23(was studied.the main subject of this study was the highly reve...
BACKGROUND 1,4-Diazepine derivatives are the seven membered, nitrogen containing heterocyclic ring systems possessing a wide range of therapeutic applications. 1,4-Diazepines attracted the attention of chemists and druggists due to their biological and medicinal properties, such as antimicrobial, anti-HIV and anticancer activities. Herein, we report the preparation, crystal structure determined...
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