Human liver cancers have been associated mainly with chronic inflammations such as viral hepatitis B or C. This suggests that prolonged cell damage by chronic inflammation is critical in cancer development. Overproduction of nitric oxide (NO.) and its derivative (NOx, peroxynitrite) has been implicated as a cause of tissue damage by inflammation, thus contributing to tumor promotion. We have de...

Effects of garlic (Allium sativum) on circulatory lipid peroxidation and antioxidant status were evaluated in N-Nitrosodiethylamine induced hepatocarcinogenesis in male rats. Enhanced lipid peroxidation in the circulation of NNitrosodiethylamine (NDEA) treated rats was accompanied by a decrease in the levels of vitamins C and E, reduced glutathione, glutathione peroxidase, superoxide dismutase ...

The question of whether 8-hydroxyguanine (8-OHG) formation is involved in initiation by low dose levels of N-nitrosodiethylamine (DEN) was addressed using a rat liver model. Male Fischer 344 rats, 6 weeks of age, were administered single i.p. doses of DEN between 0.001 and 100 mg/kg body weight. The 8-OHG levels in liver DNA were measured within 72 h thereafter in randomly selected rats. The re...