We assessed the incidence, prognostic features, and outcomes associated with transformation of follicular lymphoma (FL) among 2652 evaluable patients prospectively enrolled in the National LymphoCare Study. At a median follow-up of 6.8 years, 379/2652 (14.3%) patients transformed following the initial FL diagnosis, including 147 pathologically confirmed and 232 clinically suspected cases. Easte...

BACKGROUND Several studies have found an effect on mortality of between-city contrasts in long-term exposure to air pollution. The effect of within-city contrasts is still poorly understood. OBJECTIVES We studied the association between long-term exposure to traffic-related air pollution and mortality in a Dutch cohort. METHODS We used data from an ongoing cohort study on diet and cancer wi...

Bistatic forward-looking SAR (BFSAR) is a kind of bistatic synthetic aperture radar (SAR) system that can image forward-looking terrain in the flight direction of an aircraft. Until now, BFSAR imaging theories and methods for a stationary scene have been researched thoroughly. However, for moving-target imaging with BFSAR, the non-cooperative movement of the moving target induces some new issue...

Nanostructured Lipid Carriers (NLC) are nano-sized colloidal drug delivery system that contains a lipid mixture consisting of both solid and liquid lipids in their core. This Lipid-Based Nanosystem is introduced as biocompatible, non-toxic, safe nano-drug compared to polymeric or metallic nanoparticles. Due its safety, stability, high loading capacity other lipid-based nanocarriers, NLC gained ...

PURPOSE Nanostructured lipid carrier (NLC) is a useful delivery system with high capacity for bioactive loading, and suitable stability for fortification of foods and beverages. The objective of the present work is to prepare vitamin A palmitate (vitA)-loaded NLC and to investigate surfactant concentration effect on physicochemical properties of prepared formulation. METHODS VitA-loaded NLC w...

Use case scenarios are often used for conducting requirements inspection and other relevant downstream activities. While working with industrial partners, we discovered that an automated solution is required for optimally selecting a subset of use case scenarios, aiming to enable cost-effective requirements inspection. In this paper, relying on a natural language based use case modeling methodo...

The purpose of this study was to investigate the loading properties non-psychoactive cannabidiol (CBD) in a new nanostructured lipid carrier (NLC), evaluating its bioaccessibility gastric and intestinal simulated physiological media. CBD has low water solubility, as well high instability conditions acidic media, which results very bioavailability—less than 6%. NLCs containing (10 mg/mL), Compri...

Photodynamic therapy (PDT) is a promising alternative approach for improved cancer treatment. In PDT, a photosensitizer (PS) is administered that can be activated by light of a specific wavelength, which causes selective damage to the tumor and its surrounding vasculature. The success of PDT is limited by the difficulty in administering photosensitizers (PSs) with low water solubility, which co...

We present a new method for the in-plane realignment of nematic liquid crystals in already fully assembled cells with uni-directionally rubbed polyimide as an aligning layer. We use nematic liquid crystals (NLCs) with a relatively high nematic-isotropic transition temperature and we focus the IR laser beam of the laser tweezers selectively onto one or the other of the inner interfaces. The heat...