BACKGROUND Toxoplasma gondii is an important zoonotic pathogen. Vertical transmission of the parasite occurs when females were infected primarily during gestation. This parasite is transmitted to the fetus through the placenta and may cause miscarriage, permanent neurological damage, premature birth and visual impairment. It has been found that mouse is susceptible to Toxoplasma and is particul...

OBJECTIVE There is a wide application of titanium dioxide (TiO2) nanoparticles (NPs) in industry. These particles are used in various products, and they also has biological effects on cells and organs through direct contact. MATERIALS AND METHODS In this experimental research, the effect of TiO2 on chondrogenesis of forelimb buds of mice embryos was assessed in in vivo condition. Concentratio...

OBJECTIVES Recent evidence have proposed that Tretinoin produced in the gut preferentially promote differentiation of FoxP3+Treg cells but inhibits Th17 lymphocytes, and this may be the main immunomdulatory mechanism of Tretinoin in vivo. This study was done to investigate the effects of Tretinoin in outbred white mice after challenge with sheep red blood cells (SRBC). MATERIALS AND METHODS T...

PL-10.1.AK-15 is an active fragment of a naturally occurring protein first isolated from human gastric juice. Among its other protective effects, PL-10.1.AK-15 has demonstrated a protective effect on the gastrointestinal tract. The aim of this study was to investigate the influence of PL-10.1.AK-15 on two functional parameters of gastrointestinal function: gastric acid secretion and gastrointes...

BACKGROUND Aging contains morphological and functional deterioration in biological systems. D-galactose (D-gal) generates free radicals and accelerates aging. Portulaca oleracea (Purslane) may have protective effect against oxidative stress. OBJECTIVE Purslane ethanolic extract effects were evaluated on antioxidant indices and sex hormone in D-gal aging female mice. MATERIALS AND METHODS 48...

BACKGROUND Methamphetamine (MA) was shown to have harmful effects on male reproductive system. OBJECTIVE To investigate probable effects of daily administration of MA on sperm parameters and chromatin/DNA integrity in mouse. MATERIAL AND METHODS Thirty-five NMRI male mice were divided into five groups including low, medium, and high dosage groups which were injected intraperitoneally with 4...

The most critical bottleneck in the generation of recombinant Plasmodium berghei parasites is the mandatory in vivo cloning step following successful genetic manipulation. This study describes a new technique for rapid selection of recombinant P. berghei parasites. The method is based on flow cytometry to isolate isogenic parasite lines and represents a major advance for the field, in that it w...

Biofiltration is one of the air pollution control technologies that utilizes the microorganisms to biologically degrade Volatile Organic Compounds (VOCs) and odor contained in waste air streams. The microorganism exists on the surface and in a thin water film surrounding the surface of biofilter material and degrades the pollutants present in the fluid. This method is distinguished from other b...