BACKGROUND AND PURPOSE Clinicians need valid and easily applicable predictors of outcome in patients with hip fracture. Adjusting for previously established predictors, we determined the predictive value of the New Mobility score (NMS) for in-hospital outcome in patients with hip fracture. PATIENTS AND METHODS We studied 280 patients with a median age of 81 (interquartile range 72-86) years w...

The syndromes of psychosis, intermittent hyponatraemia and polydipsia (PIP) and neuroleptic malignant syndrome (NMS) are rare. Rarer still is their concomitant occurrence. This case report describes a 44 year old, schizophrenic, Caucasian female who presented with vomiting and confusion. A subsequent seizure and fluctuating consciousness prompted rapid investigation revealing a very low sodium ...

The field of nanotoxicology has made tremendous progress identifying novel and potentially adverse biological effects following nanomaterial (NM) exposure. However, one facet yet to be satisfactorily explored is how a physiological environment modifies NM physicochemical properties, thus introducing novel complexities associated with solid phase material exposures. In this study, artificial alv...

Sepsis is the leading cause of mortality among foals less than one week of age. Previous studies indicate elevated oxytocin in response to sepsis associated stress and decreased concentration with neurological dysfunction in critically ill human neonates, but limited information exists in newborn foals. Neonatal maladjustment syndrome (NMS) occurs in foals during or shortly after parturition, i...

Native mass spectrometry (nMS) screening of natural glycan libraries against glycan-binding proteins (GBPs) is a powerful tool for ligand discovery. However, as the concentrations are unknown, affinities cannot be measured directly from libraries. Here, we introduce Concentration-Independent (COIN)-nMS, which enables quantitative by exploiting slow mixing solutions inside nanoflow electrospray ...

Monopolar spindle 1 (Mps1/TTK) is a protein kinase essential in mitotic checkpoint signaling, preventing anaphase until all chromosomes are properly attached to spindle microtubules. Mps1 has emerged as a potential target for cancer therapy, and a variety of compounds have been developed to inhibit its kinase activity. Mutations in the catalytic domain of Mps1 that give rise to inhibitor resist...

Neuromelanins (NMs) are neuronal pigments of melanic-lipidic type which accumulate during aging. They are involved in protective and degenerative mechanisms depending on the cellular context, however their structures are still poorly understood. NMs from nine human brain areas were analyzed in detail. Elemental analysis led to identification of three types of NM, while infrared spectroscopy sho...

INTRODUCTION Neuroleptic malignant syndrome (NMS) is a rare, but sometimes fatal, adverse reaction to neuroleptics characterized principally by fever and rigor. The aim of this study was to prove the efficacy of different NMS treatment strategies, focusing on the efficacy of dantrolene. METHODS Altogether, 271 case reports were included. These cases were categorized into four treatment groups...

To test whether cerebral autoregulation is impaired in patients with neurally mediated syncope (NMS), we evaluated 15 normal subjects and 37 patients with recurrent NMS. Blood pressure (BP), heart rate, and cerebral blood velocity (CBV) (transcranial Doppler) were recorded at rest and during 80 degrees head-up tilt (HUT). Static cerebral autoregulation as assessed from the change in cerebrovasc...

The European Union-United States Communities of Research were established in 2012 to provide a platform for scientists to develop a "shared repertoire of protocols and methods to overcome nanotechnology environmental health and safety (nanoEHS) research gaps and barriers" (www.us-eu.org/). Based on work within the Ecotoxicology Community of Research (2012-2015) the present Focus article provide...