AIMS To assess the relative frequency of mitotic and apoptotic cells in malignant melanoma and basal cell carcinoma. METHODS Retrospective evaluation of haematoxylin and eosin stained slides from 10 basal cell carcinomas, 10 nodular melanomas, and 10 superficial spreading melanomas, with counting of apoptotic and mitotic cells per 1000 cells. Selected cases were studied with in situ end-label...

Atypical fibroxanthoma (AFX) is a nodular dermal ulcerative lesion with a favorable prognosis. AFX most commonly occurs on sun-exposed skin in elderly individuals. AFX is characterized by its association with ultraviolet radiation, not only from a clinical aspect, but also from a molecular aspect. Making a diagnosis of AFX is challenging, and it is important to differentiate it from squamous ce...

Introduction and purpose Uveal melanoma is the most common primary intraocular malignancy in adults. Most of them arise choroid ciliary body, whereas 2-5 % cases are located to iris. Nevertheless, during last few decades incidence this neoplasm has been increasing. The aim study discuss risk factors, clinical features methods diagnosis treatment iris melanoma. Description state knowledge Iris m...

Abstract The steep increase in incidence of cutaneous malignant melanoma white populations mainly applies to thin lesions with good survival suggesting overdiagnosis. Based on population‐based cancer registries (CRs), we have investigated changes aggressive melanoma, selecting only cases who died within 1 or 3 years after diagnosis 11 European countries between 1995 and 2012. Trends fatal were ...

Multiple primary malignancies (MPMs) are present when a patient is diagnosed with more than one primary malignancy and when each tumor is histologically unrelated to the others. MPMs are considered synchronous when they present within 6 months of one another. Here, we report the case of a 57-year-old woman with a past medical history significant for melanoma in 1988, who presented in 2014 with ...

OBJECTIVE To compare the effect of differing health care delivery models, specifically, gatekeeper (GK) vs direct access (DA) routes, on melanoma outcome as measured by tumor thickness and cancer stage at diagnosis. DESIGN Retrospective medical record review of patients previously diagnosed as having cutaneous melanoma who were referred to a university-based clinic from January 1, 1996, throu...

BACKGROUND Population-based data on melanoma survival are important for understanding the impact of demographic and clinical factors on prognosis. OBJECTIVE We describe melanoma survival by age, sex, race/ethnicity, stage, depth, histology, and site. METHODS Using Surveillance, Epidemiology, and End Results data, we calculated unadjusted cause-specific survival up to 10 years from diagnosis...