نتایج جستجو برای: non infiltrating
تعداد نتایج: 1328460 فیلتر نتایج به سال:
A sinister and stealthy marauder, infiltrating lobular carcinoma (ILC) can potentially elude detection due to its pathologic appearance. As reviewed in the last issue of The WCC Note, the shape of ILC at pathology varies. It ranges from tumors with irregular margins; to those displaying diffuse invasion with cells infiltrating single file or loosely associated; to variants with large groups of ...
ACT with in vitro expanded populations of T cells, generated from tumor infiltrating lymphocytes, has shown remarkable results in human tumor immunotherapy [1-6]. These approaches are based on fundamental principles underlying T cell activation and effector function [7-9]. Unfortunately, while these approaches have proved therapeutically quite useful, various biological processes that regulate ...
CD8+ T cells in progressing tumors frequently fail to mount an effective antitumor response often in association with the expression of inhibitory receptors, including programmed cell death-1 (PD-1) and lymphocyte-activation gene 3 (Lag3). Using a lymphoma tumor model, we demonstrate that tumor-infiltrating CD8+ T cells from growing tumors co-express inhibitory receptors and co-stimulatory rece...
To investigate mechanisms of cell-mediated injury in renal inflammatory disease it is critical to determine the surface phenotype of infiltrating renal leukocyte subsets. However, the cell-specific expression of many leukocyte receptors is difficult to characterize in vivo. Here, we report a protocol based on flow cytometry that allows simultaneous characterization of surface receptor expressio...
Neuroendocrine differentiation has been reported in both in situ and infiltrating breast cancers. The prognostic significance of neuroendocrine differentiation in mammary carcinoma is unclear. The spectrum ranges from undifferentiated small cell carcinoma to ductal carcinoma in situ with neuroendocrine differentiation. Mucinous carcinomas of the breast appear to have the greatest association wi...
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