Alopecia areata (AA) is an autoimmune disease due to T cell attack of observation made in a special patient is complemented with mechanisthe hair follicles and breakdown of their immune privilege resulting in transient non-scarring hair loss which may last from weeks to decades and which presents an enormous psychological burden. As so far no FDA approved successful treatments for AA are availa...

Scalp involvement with hair loss is common in systemic lupus erythematosus. Discoid erythematosus may cause scarring alopecia, characterized by well-delimited erythematous plaques scales, follicular hyperkeratosis and atrophy, which considered a trichological emergency. Early diagnosis treatment are necessary order to prevent permanent loss. We describe 44 years’ old female patient for 4 years,...

Background: Alopecia areata (AA) is the most common type of non-scarring inflammatory alopecia. Objectives: To identify a molecular signature lesional scalp in AA by genes expression microarray-derived meta-analysis. Methods: A meta-analytic model was used to integrate gene profiles from five independent Gene Expression Omnibus (GEO) datasets (GSE68801, GSE45512, GSE80342, GSE58573, GSE74761) i...

Alopecia areata (AA) is one of the most common causes of non-scarring hair loss, which is associated with the premature induction of hair follicle regression. The pathogenesis of AA is unknown, although it is believed that a complicated autoimmune mechanism with Th1 lymphocytes and proinfammatory cytokines, such as IFN-γ, TNF-α, IL-1 and IL-2, may be involved. AA may occur as a single disease e...

A 20-months-old infant was admitted with prolonged fever, bilateral non-purulent conjunctivitis, strawberry tongue, lip cracking and maculopapular rash. Left branch coronary aneurysm formation was detected in Color-Doppler echocardiography. The diagnosis was Kawasaki disease. After 6 weeks, he had alopecia totalis. Although, alopecia areata has been seen in Kawasaki disease, but alopecia totali...

Alopecia areata is a common condition with patchy non scarring hair loss. We report a case of an 11 year old male child with localized patch of hair loss on the frontoparietal region of the scalp since one year. It was a widespread extensive patch of hair loss covering more than 40% of the scalp. On hair shaft microscopy, numerous exclamation mark hairs were present. The patient was put on topi...

Sir, The anti-convulsant drug carbamazepine may induce generalized exanthema or, less frequently, severe cutaneous eruptions, such as hypersensitivity syndrome or toxic epidermal necrolysis. The development of psoriasiform eruptions and the exacerbation of pre-existing psoriasis have been recognized as common adverse reactions to beta-blockers, lithium and antimalarials (1). Additional causativ...

Primer Cicatricial Alopecias (PCAs) are a group of autoinflammatory disorders characterized by scarring the hair follicle and result is irreversible loss. CD8+ T cells attack epithelial stem (eHFSCs) in bulge follicle, fibrosis ultimately leads to Immune privilege collapse plays role pathogenesis alopecia areata, though its loss not fully characterized. We developed an inducible mouse model tha...

Tinea capitis is unusual and often misdiagnosed in healthy adults. We report a case of a healthy woman with a several-year history of asymptomatic, bizarre-shaped, non-scarring alopecia. She had used over-the-counter ketoconazole shampoo regularly for a long time. An initial potassium hydroxide preparation showed negative result for fungal organism. The scalp biopsy revealed endothrix infection...