1. Abstract 2. Introduction 3. Viral vectors 3.1. Adenoviral vectors 3.2. Adeno-associatedvectors 3.3. Retroand Lentiviral vectors 3.4. Herpes viral vectors 4. Chemical gene transfer 5. Physical methods for gene delivery 5.1. Ballistic gene delivery 5.2. Micorseeding 5.3. Electroporation 6. Gene regulation 7. Gene silencing and transcriptional factors 8. Clinical trials 9. Perspective 10. Refer...

Recently several systems including viral and non-viral carriers that can be used to transfer foreign genetic material into cells have been developed with the aim of enhancing gene transfer in vivo. Non-viral vectors are relatively easy to produce in clinically relevant quantities, and associated with fewer safety concerns. Furthermore, synthetic non-viral vectors provide flexibility in formulat...

background and objectives: baculovirus can be used as a vector in gene delivery system. viral envelope of baculovirus would display expressed protein/peptide and it could render as a potential vaccine delivery system. in this regard, the gene coding for a subunit of shiga toxin (stxa) from escherichia coli ( e. coli ) strain was cloned in a baculovirus expression system. stxa subunit has the ab...

Adeno-associated viral (AAV) vector-mediated gene replacement for the treatment of muscular dystrophy represents a promising therapeutic strategy in modern medicine. One major obstacle in using AAV vectors for in vivo gene delivery is the development of host immune responses to the viral capsid protein and transgene products as evidenced in animal models and human trials for a range of genetic ...

RALA is a cationic amphipathic peptide which has shown great promise as an efficient, multifunctional delivery system for the of nucleic acids. Rational design was utilised in this study to understand essential amino acids required and if any improvements could be made. Six peptides were synthesised with strategic sequences acid substitutions reduce sequence, while maintaining functional charac...