INTRODUCTION Neurodegenerative disease diagnoses may be supported by the comparison of an individual patient's brain magnetic resonance image (MRI) with a voxel-based atlas of normal brain MRI. Most current brain MRI atlases are of young to middle-aged adults and parametric, e.g., mean ± standard deviation (SD); these atlases require data to be Gaussian. Brain MRI data, e.g., grey matter (GM) p...

Statistical Software SigmaStat is a statistical software package that performs such computations as t tests, analyses of variance, correlations, rates and proportions, nonparametric methods, linear and nonlinear regressions, and power and sample size analyses. SigmaStat's procedures are automated and require little statistical knowledge from the user. An "Advise" command helps the user select t...

G. J. Babu has diverse research interests in both statistics and probability, and their applications to problems in biomedical research, Population Genetics, astronomy and astrophysics. His research interests have varied over the years. He has contributed extensively to probabilistic number theory, resampling methods, nonparametric methods and asymptotic theory. He published seven books and ove...

This article describes the use of Bayesian methods in the statistical analysis of time series. The use of Markov chain Monte Carlo methods has made even the more complex time series models amenable to Bayesian analysis. Models discussed in some detail are ARIMA models and their fractionally integrated counterparts, state-space models, Markov switching and mixture models, and models allowing for...

This article describes the use of Bayesian methods in the statistical analysis of time series. The use of Markov chain Monte Carlo methods has made even the more complex time series models amenable to Bayesian analysis. Models discussed in some detail are ARIMA models and their fractionally integrated counterparts, state-space models, Markov switching and mixture models, and models allowing for...

functional magnetic resonance imaging (fmri) is a safe and non-invasive way to assess brain functions by using signal changes associated with brain activity. the technique has become a ubiquitous tool in basic, clinical and cognitive neuroscience. this method can measure little metabolism changes that occur in active part of the brain. we process the fmri data to be able to find the parts of br...

Glossary Hypothesis A hypothesis is a statement concerning the (joint) distribution underlying the observed data. Nonparametric test In contrast to a parametric test, a nonparametric test does not presume a particular parametric structure concerning the data generating process. Serial dependence Statistical dependence among time series observations.