The aim of this paper is to make sense of cases of apparent nonsense in the writings of Kierkegaard and Wittgenstein. Against commentators such as Cora Diamond and James Conant, we argue that, in the case of Wittgenstein, recognising such a category of nonsense is necessary in order to understand the development of his thought. In the case of Kierkegaard, we argue against the view that the noti...

Mutations that result in the loss of the protein dysferlin result in defective muscle membrane repair and cause either a form of limb girdle muscular dystrophy (type 2B) or Miyoshi myopathy. Most patients are compound heterozygotes, often carrying one allele with a nonsense mutation. Using dysferlin-deficient mouse and human myocytes, we demonstrated that membrane blebbing in skeletal muscle my...

Nonsense-mediated decay (NMD) eliminates mRNAs that prematurely terminate translation. We used antibody to the nuclear cap binding protein CBP80 or its cytoplasmic counterpart eIF4E to immunopurify RNP containing nonsense-free or nonsense-containing transcripts. Data indicate that NMD takes place in association with CBP80. We defined other components of NMD-susceptible mRNP as CBP20, PABP2, eIF...