Heterotopic pregnancy is rare under natural circumstance (conception). We report the first case of heterotopic pregnancy in spontaneous conception with four previous caesarean sections and ruptured tubal ectopic with resultant successful normal intra-uterine pregnancy delivered at term after salpingectomy. A 32-year-old gravida 5 para 4+0 with 3 living children, with 4 previous caesarean sectio...

AimsTo evaluate the importance and usefulness of fasting plasma glucose (FPG) in first trimester predicting adverse pregnancy outcomes.MethodsA retrospective study 22,398 singleton pregnancies was conducted. Participants were divided into subgroups according to first-trimester FPG (low FPG, < 5.1 mmol/L; medium mmol/L ≤ 5.6 high 7.0 mmol/L) oral tolerance test(OGTT) results (normal abnormal) du...

Eclampsia, clinically defined as unexplained seizure in a woman with preeclampsia, is a life threatening complication unique to the pregnant state. However, a subpopulation of women with seemingly uncomplicated pregnancies experience de novo seizure without preeclamptic signs or symptoms, suggesting pregnancy alone may predispose the brain to seizure. Here, we hypothesized that normal pregnancy...

BACKGROUND Gestational thyroid dysfunction is common and associated with maternal and child morbidity and mortality. During pregnancy, profound changes in thyroid physiology occur, resulting in different thyroid-stimulating hormone (TSH) and free thyroxine (FT4) reference intervals compared to the nonpregnant state. Therefore, international guidelines recommend calculating trimester- and assay-...

Understanding cardiovascular physiological adaptation to pregnancy is particularly important in elucidating the pathophysiology and management of hypertensive disorders of pregnancy—still one of the most common causes of maternal morbidity and mortality worldwide. Functional changes of the heart in pregnancy have been widely investigated during the last few decades with relatively inconsistent ...

To assess the contribution of the arterial and venous systems in the hemodynamic changes of normal pregnancy, we studied blood flow, vascular resistance, venous tone, and the viscoelastic properties ("creep") of the upper and lower limbs (using plethysmography), aortic distensibility (using pulse wave velocity measurements), and cardiac dimensions (using echocardiography) in nine healthy women....

Simultaneous determination of maternal and fetal plasma 11-deoxycorticosterone (DOC), corticosterone (B), 18-hydroxycorticosterone (18OH-B) and aldosterone (ALDO) in normal and toxemic pregnancies was performed by utilizing a newly developed radioimmunoassay. The mean levels of plasma DOC and ALDO in normal term pregnancy were significantly higher than those of nonpregnant women. Comparing the ...

Despite the well-known influence of maternal glucose on infant birth weight (BW), the prevalence of large for gestational age (LGA) infants ($90th percentile for age) has been increasing steadily over decades, particularly in pregnancies complicated by pregestational or gestational diabetes mellitus (1). Although the overall prevalence of macrosomia (BW$4,000 g) is 17–29% in women with untreate...

0.0001 by Wilcoxon signed-rank test) and based on the 99th percentile values for each assay, 9 discordances were found between assays for values within the reference interval vs increased values. The ADVIA TnI-Ultra method showed no interference from dilutions with plasma samples that contained high concentration of triglycerides (6.6 g/L, final dilution 1:128; y 0.044 0.14x, n 8, R 0.99) or he...

The purpose of this study was to evaluate a quantitative analysis of the nociceptive threshold, using the current perception threshold (CPT), in women with normal pregnancies and to assess the relationship between nociceptive thresholds and ovarian sex steroids. The subjects consisted of 10 women with singleton pregnancies and 14 age-matched healthy female volunteers. The CPTs (5,250, and 2,000...