AIM To elucidate the distribution and regulation of Neuropeptide Y (NPY) gene expression in testes under physiological and pathophysiological conditions, such as testicular development, fasting and experimental cryptorchidism. METHODS In the first experiment, C57BL/6J male mice at the ages of 3 days as well as 2, 3, 5 and 8 weeks were used. In the second and third experiments, adult C57BL/6J ...

The aim of the present work was to find out whether NPY synthesized in human adrenal chromaffin cells controls in an autocrine/paracrine fashion the release of catecholamines by these cells. Accordingly, the constitutive and regulated release of both NPY and catecholamines was measured simultaneously in cultured human chromaffin cells. In addition, by using both RT-PCR and a combination of spec...

Neuropeptide Y (NPY) is far more abundant in the dentate gyrus than elsewhere in the hippocampal formation, but it does not alter the synaptic excitation of dentate granule cells (DGCs) as it does for pyramidal cells in areas CA1 and CA3. NPY inhibited depolarization-induced increases in intracellular Ca2+ concentrations ([Ca2+]i) in DGCs in hippocampal slices, without altering the resting [Ca2...

Previous studies have suggested that neuropeptide Y (NPY) in the dorsomedial hypothalamus (DMH) serves as an important signaling peptide in the regulation of energy balance. To elucidate such actions, we used the adenoassociated virus (AAV) system to alter Npy gene expression in the DMH and examined the effects of these alterations on food intake and energy balance as well as explored its downs...

Neuropeptide Y (NPY), a 36‐amino‐acid peptide is abundantly expressed throughout the mammalian nervous system including: neocortex, hippocampus, striatum, amygdala, hypothalamus, thalamus, and brain stem. NPY has been implicated in the regulation of a number of different behaviors and neurophysiological functions, many of them part of the complex system(s) involved in maintaining and regulating...

When neuropeptide Y (NPY) is administered centrally, meal-anticipatory responses are elicited. If an increase of endogenous NPY is a signal that heralds an imminent large caloric load, timed daily NPY injections may be expected to condition meal-anticipatory responses that facilitate ingestion. Rats received 4-h access to food beginning in the morning and then timed (1600 h), daily third-ventri...

IT HAS BEEN a long-standing observation that overnutrition during the early lifetime can have a permanent influence on the feeding behavior and body weight gain of the adult individual. The maintenance of energy balance, which is the resultant of energy intake and expenditure, is controlled by a complex network of neurohumoral factors (2, 5, 10). Among those, neuropeptide Y (NPY), a 36-amino ac...

The role of neuropeptide Y (NPY) in feeding behavior and zinc deficiency-induced anorexia has been controversial because hypothalamic NPY levels are elevated in both zinc deficiency and food restriction. A recent report shows that while NPY is released from terminals in the paraventricular nucleus of the hypothalamus of food-restricted animals, this release is significantly impaired in zinc-def...

The aim of the present study was to investigate usefulness multidrug resistance protein 1 (MDR1) and neuropeptide Y (NPY) levels in predicting efficacy levetiracetam (LEV) plus oxcarbazepine (OXC) treatment administered children with epilepsy determine their prognosis. Overall, 193 admitted hospital were enrolled randomly divided into two groups according different methods: group A (n = 106, tr...

Machado-Joseph disease (MJD) is a fatal, dominantly inherited neurodegenerative disorder associated with an expanded polyglutamine tract within the ataxin-3 protein, and characterized by progressive impairment of motor coordination, associated with neurodegeneration of specific brain regions, including cerebellum and striatum. The currently available therapies do not allow modification of disea...