نتایج جستجو برای: nras
تعداد نتایج: 2055 فیلتر نتایج به سال:
Repeat tumor biopsies to study genomic changes during therapy are difficult, invasive and data are confounded by tumoral heterogeneity. The analysis of circulating tumor DNA (ctDNA) can provide a non-invasive approach to assess prognosis and the genetic evolution of tumors in response to therapy. Mutation-specific droplet digital PCR was used to measure plasma concentrations of oncogenic BRAF a...
ZnO nanorod arrays (NRAs) on transparent conductive oxide (TCO) films have been grown by a solution-free, catalyst-free, vapor-phase synthesis method at 600°C. TCO films, Al-doped ZnO films, were deposited on quartz substrates by magnetron sputtering. In order to study the effect of the growth duration on the morphological and optical properties of NRAs, the growth duration was changed from 3 t...
Deregulation of microRNAs' expression frequently occurs in acute myeloid leukemia (AML). Lower miR-181a expression is associated with worse outcomes, but the exact mechanisms by which miR-181a mediates this effect remain elusive. Aberrant activation of the RAS pathway contributes to myeloid leukemogenesis. Here, we report that miR-181a directly binds to 3'-untranslated regions (UTRs); downregul...
BACKGROUND Thyroid nodules are common but only a minority are malignant. Molecular testing can assist in helping determine whether indeterminate nodules are suspicious for malignancy or benign. The objective of the study was to determine if the analysis of mutations (BRAF, NRAS, KRAS and HRAS) using readily available molecular techniques can help better classify indeterminate thyroid nodules. ...
The PI3K/AKT/mTOR pathway plays a major role in melanoma pathogenesis and is also involved resistance to targeted therapies (TT). mTORC2 complex an important this therefore contributes the development of BRAF-mutated (BRAFm) melanomas their treatments. goal our project study order target it specifically. For purpose, we are focusing more particularly on one principal protein complex: SIN1 (also...
Right-sided colorectal cancer (RCRC) is associated with several negative clinicopathological and molecular features also worse survival than left-sided (LCRC). A recent study has shown an association between RCRC increased incidence of venous thromboembolism (VTE). However, the role RAS/BRAF mutations considering risk VTE in metastatic (mCRC) remains unclear. The aim our was to examine impact t...
Phosphinoamide ligands have been utilized to link a Co(I) center to a Nb or Ta imido fragment. The resulting heterobimetallic complexes, ICo(Ph(2)PN(i)Pr)(3)M=N(t)Bu, have weakened dative metal-metal interactions as a result of the strongly donating imido ligand. These complexes can be reduced by 2 electrons to generate dinitrogen-bound complexes.
The pathogenesis of acute myeloid leukemia (AML) involves the cooperation of mutations promoting proliferation/survival and those impairing differentiation. The RAS pathway has been implicated as a key component of the proliferative drive in AML. We have screened AML patients, predominantly younger than 60 years and treated within 2 clinical trials, for NRAS (n = 1106), KRAS (n = 739), and HRAS...
Palmitoylation is postulated to regulate Ras signaling by modulating its intracellular trafficking and membrane microenvironment. The mechanisms by which palmitoylation contributes to these events are poorly understood. Here, we show that dynamic turnover of palmitate regulates the intracellular trafficking of HRas and NRas to and from the Golgi complex by shifting the protein between vesicular...
The Ras family of small membrane-associated GTP-ases are important components in many different cell signalling cascades. They are thought to cluster on the cell membrane through association with cholesterol-rich nanodomains. This process remains poorly understood. Here we test the effect of adding multiple copies of NRas, one of the canonical Ras proteins, to a three-component lipid bilayer th...
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