نتایج جستجو برای: ns gene

تعداد نتایج: 1165584  

Journal: :Molecular pharmacology 2006
Oscar Casis Søren-Peter Olesen Michael C Sanguinetti

1,3-Bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) is a newly discovered activator of human ether-a-go-go-related gene (hERG) K(+) channels. Here, we characterize the effects of this compound on cloned hERG channels heterologously expressed in Xenopus laevis oocytes. When assessed with 2-s depolarizations, NS1643 enhanced the magnitude of wild-type hERG current in a concentration- and v...

Journal: :Microbiology 2008
Rosa C Baños José I Pons Cristina Madrid Antonio Juárez

The H-NS protein plays a significant role in the modulation of gene expression in Gram-negative bacteria. Whereas isolation and characterization of hns mutants in Escherichia coli, Salmonella and Shigella represented critical steps to gain insight into the modulatory role of H-NS, it has hitherto not been possible to isolate hns mutants in Yersinia. The hns mutation is considered to be deleteri...

2015
Mostafa Ganjuri Jamal Moshtaghian Kamran Ghaedi

OBJECTIVE Nanotechnology focuses on materials having at least one dimension of less than 100 nanometers. Nanomaterials such as Nanosilver (NS) have unique physical and chemical properties such as size, shape, surface charge. NS particles are thought to in- duce neuronal degeneration and necrosis in the brain. It has been reported that NS parti- cles generate free radicals and oxidative stress w...

Journal: :American journal of medical genetics. Part A 2010
Murat Derbent Yekta Öncel Kürşad Tokel Birgül Varan Ayşegül Haberal A Canan Yazici Eric Legius Namik Özbek

Reports on Noonan syndrome (NS) have documented multiple types of coagulation defects and bleeding diathesis, and a wide range of clinical presentations. Early studies suggested that a large proportion of NS patients have coagulation defects, whereas more recent reports indicate low rates of coagulopathy. The aim of this study was to evaluate phenotypic characteristics, PTPN11 gene mutations, a...

2012
Kelsie L. Thu Emily A. Vucic Raj Chari Wei Zhang William W. Lockwood John C. English Rong Fu Pei Wang Ziding Feng Calum E. MacAulay Adi F. Gazdar Stephen Lam Wan L. Lam

Recent evidence suggests that the observed clinical distinctions between lung tumors in smokers and never smokers (NS) extend beyond specific gene mutations, such as EGFR, EML4-ALK, and KRAS, some of which have been translated into targeted therapies. However, the molecular alterations identified thus far cannot explain all of the clinical and biological disparities observed in lung tumors of N...

Journal: :Soft matter 2013
Ce Zhang Durgarao Guttula Fan Liu Piravi P Malar Siow Yee Ng Liang Dai Patrick S Doyle Jeroen A van Kan Johan R C van der Maarel

The effect of the bacterial heat-stable nucleoid-structuring protein (H-NS) on the conformation of single DNA molecules confined in a nanochannel was investigated with fluorescence microscopy. With increasing concentration of H-NS, the DNA molecules either elongate or contract. The conformational response is related to filamentation of H-NS on DNA through oligomerization and H-NS mediated bridg...

Journal: :Twin research : the official journal of the International Society for Twin Studies 2004
Arpana Agrawal K C Jacobson C A Prescott Kenneth S Kendler

Although personality measures such as neuroticism (N), extraversion (E) and novelty-seeking (NS) are associated with the use and abuse/dependence of illicit drugs, little is known about the degree to which these associations are due to genetic or environmental factors. The goal of this analysis was to estimate the extent of genetic and environmental overlap between three dimensions of personali...

2012
Marc Solomon

One commonly used, yet little understood method for transferring DNA into cells is the temperature shock transformation method (TST) that exposes competent bacteria to successive temperatures (4C and 42C). This study tested the effect of the gene for the heatstable nucleoid structuring protein (H-NS) on the efficiency of the TST method in an effort to find a way to improve the transformation ef...

Journal: :The EMBO journal 1998
M Falconi B Colonna G Prosseda G Micheli C O Gualerzi

The expression of plasmid-borne virF of Shigella encoding a transcriptional regulator of the AraC family, is required to initiate a cascade of events resulting in activation of several operons encoding invasion functions. H-NS, one of the main nucleoid-associated proteins, controls the temperature-dependent expression of the virulence genes by repressing the in vivo transcription of virF only b...

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